Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-nitro-5-thiocyano-benzoic acid | - |
Rattus norvegicus | |
4-maleimidylstilbene-2,2'-disulfonic acid | - |
Rattus norvegicus | |
5-((((iodoacetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid | - |
Rattus norvegicus | |
DTNB | - |
Rattus norvegicus | |
NEM | - |
Rattus norvegicus | |
p-hydroxy mercury-phenylsulfonate | - |
Rattus norvegicus | |
p-hydroxy mercurybenzoic acid | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | - |
Rattus norvegicus | 5789 | - |
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O | Rattus norvegicus | the enzyme is required for the final steps of glycogenolysis and gluconeogenesis | D-glucose + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | chemical modification of thiol groups belonging to proteins involved in the enzyme system by DTNB, NTCB and IAEDANS decrease the enzyme activity, the incubation with phosphate preventes the loss of activity, the addition of 2-mercaptoethanol allows a 50% restoration of the initial activity, however chemical modification of thiol groups by pHMPS, pHMB, AMSDS and NEM decrease the enzyme activity | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O | - |
Rattus norvegicus | D-glucose + phosphate | - |
? | |
D-glucose 6-phosphate + H2O | the enzyme is required for the final steps of glycogenolysis and gluconeogenesis | Rattus norvegicus | D-glucose + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme is multiprotein system, the transmembrane catalytic subunit and the D-glucose 6-phosphate translocase have reactive thiol groups facing the cytosol | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.5 | - |
NEM | - |
Rattus norvegicus | |
0.5 | - |
4-maleimidylstilbene-2,2'-disulfonic acid | - |
Rattus norvegicus | |
0.6 | - |
DTNB | - |
Rattus norvegicus | |
0.8 | - |
5-((((iodoacetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid | - |
Rattus norvegicus | |
2 | - |
2-nitro-5-thiocyano-benzoic acid | - |
Rattus norvegicus |