BRENDA - Enzyme Database
show all sequences of 3.1.3.78

Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways

Guittard, G.; Mortier, E.; Tronchere, H.; Firaguay, G.; Gerard, A.; Zimmermann, P.; Payrastre, B.; Nunes, J.A.; FEBS Lett. 584, 2455-2460 (2010)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
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Source Tissue
Source Tissue
Commentary
Organism
Textmining
HUT-78 cell
-
Homo sapiens
-
T-lymphocyte
-
Homo sapiens
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
HUT-78 cell
-
Homo sapiens
-
T-lymphocyte
-
Homo sapiens
-
General Information
General Information
Commentary
Organism
additional information
phosphatidylinositol 5-phosphate may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis
Homo sapiens
physiological function
PtdIns(4,5)P2 4-phosphatase expression induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a PtdIns5P interacting domain, PH-Dok-5, blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering, evaluation, overview
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
additional information
phosphatidylinositol 5-phosphate may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis
Homo sapiens
physiological function
PtdIns(4,5)P2 4-phosphatase expression induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a PtdIns5P interacting domain, PH-Dok-5, blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering, evaluation, overview
Homo sapiens
Other publictions for EC 3.1.3.78
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
715020
Guittard
Evidence for a positive role o ...
Homo sapiens
FEBS Lett.
584
2455-2460
2010
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2
2
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681168
Mason
Alteration of epithelial struc ...
Salmonella enterica
J. Gen. Physiol.
129
267-283
2007
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1
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682554
Zou
Type I phosphatidylinositol-4, ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
104
16834-16839
2007
1
1
1
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2
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1
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666740
Ungewickell
The identification and charact ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
102
18854-18859
2005
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1
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1
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4
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2
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8
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4
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4
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16
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4
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697201
Aleman
The amino-terminal non-catalyt ...
Salmonella enterica subsp. enterica serovar Typhimurium
Cell. Microbiol.
7
1432-1446
2005
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1
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7
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2
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697606
Niebuhr
Conversion of PtdIns(4,5)P(2) ...
Shigella flexneri
EMBO J.
21
5069-5078
2002
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7
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700351
Terebiznik
Elimination of host cell PtdIn ...
Salmonella enterica subsp. enterica serovar Typhimurium
Nat. Cell Biol.
4
766-773
2002
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1
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3
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