Literature summary for 3.1.3.78 extracted from

Guittard, G.; Mortier, E.; Tronchere, H.; Firaguay, G.; Gerard, A.; Zimmermann, P.; Payrastre, B.; Nunes, J.A.
Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways (2010), FEBS Lett., 584, 2455-2460.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HUT-78 cell	-	Homo sapiens	-
T-lymphocyte	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
IpgD	-	Homo sapiens
PtdIns(4,5)P2 4-phosphatase	-	Homo sapiens

General Information

General Information	Comment	Organism
additional information	phosphatidylinositol 5-phosphate may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis	Homo sapiens
physiological function	PtdIns(4,5)P2 4-phosphatase expression induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a PtdIns5P interacting domain, PH-Dok-5, blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering, evaluation, overview	Homo sapiens

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Release 2023.1 (January 2023)