Activating Compound | Comment | Organism | Structure |
---|---|---|---|
etoposide | significantly increases type I 4-phosphatase in the nuclear fraction, in both the endogenous and overexpression system | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | type I 4-phosphatase regulates nuclear phosphatidylinositol 5-phosphate levels, which in turn mediate p53-dependent apoptosis through interaction with inhibitor of growth protein-2 in response to genotoxic stress | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
stably transfected HEK-293 TRex cells in a tetracycline-inducible vector expressing type I and II 4-phosphatase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PIPKIIbeta | inhibits p53 acetylation and cell death | Homo sapiens | |
RNAi | siRNA of type I 4-phosphatase reduces type I 4-phosphatase levels, which is followed by a dramatic decrease in p53 levels in response to the genotoxic agent etoposide. siRNA of type II 4-phosphatase does not reduce p53 expression | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | when HeLa cells are treated with etoposide or doxorubicin, type I 4-phosphatase translocates to the nucleus and nuclear levels of phosphatidylinositol 5-phosphate increase | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol-4,5-bisphosphate + H2O | - |
Homo sapiens | phosphatidylinositol-5-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type I 4-phosphatase | - |
Homo sapiens |
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase | - |
Homo sapiens |
type II 4-phosphatase | - |
Homo sapiens |