BRENDA - Enzyme Database
show all sequences of 3.1.3.75

Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization

Roberts, S.; Narisawa, S.; Harmey, D.; Millan, J.L.; Farquharson, C.; J. Bone Miner. Res. 22, 617-627 (2007)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
PHOSPHO1 expression is not influenced by presence of tissue-nonspecific alkaline phosphatase
Mus musculus
Application
Application
Commentary
Organism
medicine
PHOSPHO1 plays a role in the initiation of matrix mineralization
Gallus gallus
medicine
PHOSPHO1 plays a role in the initiation of matrix mineralization
Homo sapiens
medicine
PHOSPHO1 plays a role in the initiation of matrix mineralization
Mus musculus
Cloned(Commentary)
Commentary
Organism
into vector pBAD TOPO TA, expressed in Escherichia coli
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-phenyl-1,2-benzoisoselenazol-3(2H)-one
noncompetitive inhibitor
Homo sapiens
ebselen
-
Homo sapiens
lansoprazole
1 mM decreases calcifying potential in the presence of phosphoethanolamine by 10%
Gallus gallus
lansoprazole
noncompetitive inhibitor, reduces activity by 28%
Homo sapiens
lansoprazole
inhibits the mineralization of matrix vesicles from tissue-nonspecific alkaline phosphatase deficient Akp2(-/-) osteoblasts by 56.8%
Mus musculus
SCH202676
1 mM decreases calcifying potential in the presence of phosphoethanolamine by 10%
Gallus gallus
SCH202676
noncompetitive inhibitor, reduces activity by 16%
Homo sapiens
SCH202676
inhibits the mineralization of matrix vesicles from tissue-nonspecific alkaline phosphatase deficient Akp2(-/-) osteoblasts by 70.7%
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Mus musculus
5829
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Gallus gallus
Mg2+
-
Homo sapiens
Mg2+
-
Mus musculus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
29000
-
PHOSPHO1 splice variant, Western blot analysis
Mus musculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adipose tissue
low expression, 3.38fold higher than in liver
Mus musculus
-
bone
matrix vesicles
Gallus gallus
-
bone
PHOSPHO1 is restricted to mineralizing regions of bone and growth plate. 120fold higher level of PHOSPHO1 expression in bone compared with liver. Enzyme present within matrix vesicles is in an active state. Present in early hypertrophic chondrocytes of the growth plate, and in osteoblasts of trabecular surfaces and infilling primary osteons of cortical bone
Mus musculus
-
brain
low expression, 1.96fold higher than in liver
Mus musculus
-
gut
low expression, 1.2fold higher than in liver
Mus musculus
-
heart
low expression, 5.67fold higher than in liver
Mus musculus
-
liver
lowest expression
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
O-phosphoethanolamine + H2O
-
680993
Gallus gallus
ethanolamine + phosphate
-
-
-
?
O-phosphoethanolamine + H2O
-
680993
Mus musculus
ethanolamine + phosphate
-
-
-
?
O-phosphoethanolamine + H2O
-
680993
Homo sapiens
ethanolamine + phosphate
-
-
-
?
p-nitrophenyl phosphate + H2O
-
680993
Homo sapiens
p-nitrophenol + phosphate
-
-
-
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9.6
-
-
Homo sapiens
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.00108
-
SCH202676
-
Homo sapiens
0.031
-
ebselen
-
Homo sapiens
0.07128
-
lansoprazole
-
Homo sapiens
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00197
-
-
Homo sapiens
SCH202676
0.00281
-
-
Homo sapiens
ebselen
0.00471
-
-
Homo sapiens
lansoprazole
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
PHOSPHO1 expression is not influenced by presence of tissue-nonspecific alkaline phosphatase
Mus musculus
Application (protein specific)
Application
Commentary
Organism
medicine
PHOSPHO1 plays a role in the initiation of matrix mineralization
Gallus gallus
medicine
PHOSPHO1 plays a role in the initiation of matrix mineralization
Homo sapiens
medicine
PHOSPHO1 plays a role in the initiation of matrix mineralization
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
into vector pBAD TOPO TA, expressed in Escherichia coli
Homo sapiens
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00197
-
-
Homo sapiens
SCH202676
0.00281
-
-
Homo sapiens
ebselen
0.00471
-
-
Homo sapiens
lansoprazole
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-phenyl-1,2-benzoisoselenazol-3(2H)-one
noncompetitive inhibitor
Homo sapiens
ebselen
-
Homo sapiens
lansoprazole
1 mM decreases calcifying potential in the presence of phosphoethanolamine by 10%
Gallus gallus
lansoprazole
noncompetitive inhibitor, reduces activity by 28%
Homo sapiens
lansoprazole
inhibits the mineralization of matrix vesicles from tissue-nonspecific alkaline phosphatase deficient Akp2(-/-) osteoblasts by 56.8%
Mus musculus
SCH202676
1 mM decreases calcifying potential in the presence of phosphoethanolamine by 10%
Gallus gallus
SCH202676
noncompetitive inhibitor, reduces activity by 16%
Homo sapiens
SCH202676
inhibits the mineralization of matrix vesicles from tissue-nonspecific alkaline phosphatase deficient Akp2(-/-) osteoblasts by 70.7%
Mus musculus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.00108
-
SCH202676
-
Homo sapiens
0.031
-
ebselen
-
Homo sapiens
0.07128
-
lansoprazole
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Mus musculus
5829
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Gallus gallus
Mg2+
-
Homo sapiens
Mg2+
-
Mus musculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
29000
-
PHOSPHO1 splice variant, Western blot analysis
Mus musculus
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adipose tissue
low expression, 3.38fold higher than in liver
Mus musculus
-
bone
matrix vesicles
Gallus gallus
-
bone
PHOSPHO1 is restricted to mineralizing regions of bone and growth plate. 120fold higher level of PHOSPHO1 expression in bone compared with liver. Enzyme present within matrix vesicles is in an active state. Present in early hypertrophic chondrocytes of the growth plate, and in osteoblasts of trabecular surfaces and infilling primary osteons of cortical bone
Mus musculus
-
brain
low expression, 1.96fold higher than in liver
Mus musculus
-
gut
low expression, 1.2fold higher than in liver
Mus musculus
-
heart
low expression, 5.67fold higher than in liver
Mus musculus
-
liver
lowest expression
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
O-phosphoethanolamine + H2O
-
680993
Gallus gallus
ethanolamine + phosphate
-
-
-
?
O-phosphoethanolamine + H2O
-
680993
Mus musculus
ethanolamine + phosphate
-
-
-
?
O-phosphoethanolamine + H2O
-
680993
Homo sapiens
ethanolamine + phosphate
-
-
-
?
p-nitrophenyl phosphate + H2O
-
680993
Homo sapiens
p-nitrophenol + phosphate
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9.6
-
-
Homo sapiens
Other publictions for EC 3.1.3.75
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
750176
Huang
Enhanced phosphocholine metab ...
Homo sapiens, Mus musculus
Blood
131
2955-2966
2018
-
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2
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2
2
-
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-
750211
Morcos
PHOSPHO1 is essential for nor ...
Mus musculus
Bone Joint Res.
7
397-405
2018
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3
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1
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1
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1
1
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751225
Tannert
Pi starvation-dependent regul ...
Arabidopsis thaliana
J. Exp. Bot.
69
467-481
2018
-
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1
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3
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2
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-
1
1
1
1
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-
750663
Pandya
Intravesicular phosphatase PH ...
Mus musculus
Front. Physiol.
8
805
2017
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1
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1
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3
-
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-
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-
-
-
-
-
1
1
-
-
-
751205
Zweifler
Role of PHOSPHO1 in periodont ...
Mus musculus
J. Dent. Res.
95
742-751
2016
-
-
-
-
-
-
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2
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1
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1
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
749791
Huesa
The functional co-operativity ...
Mus musculus
Biochem. Biophys. Rep.
4
196-201
2015
-
-
-
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-
-
-
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2
-
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1
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1
-
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
731455
Bravo
Design, synthesis and evaluati ...
Homo sapiens
Bioorg. Med. Chem. Lett.
24
4308-4311
2014
-
-
-
-
-
-
26
-
-
-
-
-
-
1
-
-
-
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-
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26
-
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26
26
-
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-
714360
May
Arabidopsis thaliana PECP1 - E ...
Arabidopsis thaliana
Biochim. Biophys. Acta
1824
319-325
2012
-
-
1
-
-
-
-
2
1
5
3
2
-
3
-
-
1
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-
2
1
3
2
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-
2
1
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1
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-
1
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-
-
-
-
2
1
5
3
2
-
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-
1
-
-
2
1
3
2
-
-
-
2
1
-
-
1
-
-
-
-
2
2
714357
Beassoni
Site-directed mutations and ki ...
Pseudomonas aeruginosa
Biochim. Biophys. Acta
1814
858-863
2011
-
-
1
-
3
-
1
4
-
1
-
2
-
4
-
-
-
-
-
-
4
-
3
1
1
-
-
4
1
-
-
-
-
-
-
-
-
1
-
-
3
-
-
1
-
4
-
1
-
2
-
-
-
-
-
-
4
-
3
1
1
-
-
4
1
-
-
-
-
1
1
-
4
4
714633
Huesa
PHOSPHO1 is essential for mech ...
Mus musculus
Bone
48
1066-1074
2011
-
-
-
-
1
-
-
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-
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2
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2
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2
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-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
714872
Domenech
Phosphorylcholine phosphatase: ...
Pseudomonas aeruginosa
Enzyme Res.
2011
561841
2011
-
-
1
-
1
-
5
-
-
3
-
2
-
3
-
1
1
2
-
1
-
-
5
1
-
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-
1
1
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1
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1
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5
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3
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2
-
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1
1
-
1
-
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5
1
-
-
-
-
1
1
-
-
2
1
1
2
-
-
714874
Otero
Different effects of Mg2+ and ...
Pseudomonas aeruginosa
Enzyme Res.
2011
918283
2011
-
-
1
-
-
-
9
-
-
4
-
1
-
2
-
-
-
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-
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2
-
1
-
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1
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1
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9
1
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-
4
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1
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2
-
1
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1
1
-
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-
715704
Yadav
Loss of skeletal mineralizatio ...
Mus musculus, Mus musculus C57BL/6
J. Bone Miner. Res.
26
286-297
2011
-
-
-
-
1
-
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1
-
4
-
3
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3
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4
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1
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1
-
4
-
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3
-
-
4
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
702538
Otero
Transition from octahedral to ...
Pseudomonas aeruginosa
Biometals
23
307-314
2010
-
-
1
-
-
-
1
-
-
2
-
-
-
2
-
-
1
-
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-
2
-
2
-
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1
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1
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1
1
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2
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1
-
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2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702934
MacRae
Inhibition of PHOSPHO1 activit ...
Gallus gallus
Bone
46
1146-1155
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706604
Beassoni
Preparation and biophysical ch ...
Pseudomonas aeruginosa
Protein Expr. Purif.
71
153-159
2010
-
-
1
1
2
-
-
1
-
1
2
-
-
5
-
-
1
-
1
-
-
-
1
1
-
-
1
1
1
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
1
-
1
2
-
-
-
-
1
1
-
-
-
1
1
-
-
1
1
1
-
-
-
-
-
-
-
3
3
713654
Otero
Crystallization and preliminar ...
Pseudomonas aeruginosa
Acta Crystallogr. Sect. F
66
957-960
2010
-
-
1
1
-
-
1
-
-
3
2
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
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-
-
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-
-
-
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-
1
-
1
-
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-
1
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-
3
2
1
-
-
-
1
-
-
-
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1
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