BRENDA - Enzyme Database
show all sequences of 3.1.3.75

Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes

Houston, B.; Seawright, E.; Jefferies, D.; Hoogland, E.; Lester, D.; Whitehead, C.; Farquharson, C.; Biochim. Biophys. Acta 1448, 500-506 (1999)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
sequencing
Gallus gallus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
30442
-
x * 30442, sequence calculation
Gallus gallus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Gallus gallus
3X11A participates in a biochemical pathway that is particularly active in differentiating chondrocytes, it may be involved in the generation of inorganic phosphate during matrix mineralization
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Gallus gallus
O73884
3 weeks old
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
chondrocyte
from growth plates of proximal tibiotarsi, 3X11A expression at high levels in differentiating growth plate chondrocytes, 3X11A expression is upregulated 5fold during chondrocyte terminal differentiation and its expression is approximately 100fold higher in hypertrophic chondrocytes than in non-chondrogenic tissues
Gallus gallus
-
additional information
expression pattern of 3X11A
Gallus gallus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
3X11A participates in a biochemical pathway that is particularly active in differentiating chondrocytes, it may be involved in the generation of inorganic phosphate during matrix mineralization
654794
Gallus gallus
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 30442, sequence calculation
Gallus gallus
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Gallus gallus
sequence calculation
-
7.1
Cloned(Commentary) (protein specific)
Commentary
Organism
sequencing
Gallus gallus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
30442
-
x * 30442, sequence calculation
Gallus gallus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Gallus gallus
3X11A participates in a biochemical pathway that is particularly active in differentiating chondrocytes, it may be involved in the generation of inorganic phosphate during matrix mineralization
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
chondrocyte
from growth plates of proximal tibiotarsi, 3X11A expression at high levels in differentiating growth plate chondrocytes, 3X11A expression is upregulated 5fold during chondrocyte terminal differentiation and its expression is approximately 100fold higher in hypertrophic chondrocytes than in non-chondrogenic tissues
Gallus gallus
-
additional information
expression pattern of 3X11A
Gallus gallus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
3X11A participates in a biochemical pathway that is particularly active in differentiating chondrocytes, it may be involved in the generation of inorganic phosphate during matrix mineralization
654794
Gallus gallus
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 30442, sequence calculation
Gallus gallus
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Gallus gallus
sequence calculation
-
7.1
Other publictions for EC 3.1.3.75
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
750176
Huang
Enhanced phosphocholine metab ...
Homo sapiens, Mus musculus
Blood
131
2955-2966
2018
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2
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750211
Morcos
PHOSPHO1 is essential for nor ...
Mus musculus
Bone Joint Res.
7
397-405
2018
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1
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751225
Tannert
Pi starvation-dependent regul ...
Arabidopsis thaliana
J. Exp. Bot.
69
467-481
2018
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1
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750663
Pandya
Intravesicular phosphatase PH ...
Mus musculus
Front. Physiol.
8
805
2017
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1
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1
1
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751205
Zweifler
Role of PHOSPHO1 in periodont ...
Mus musculus
J. Dent. Res.
95
742-751
2016
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1
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1
1
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749791
Huesa
The functional co-operativity ...
Mus musculus
Biochem. Biophys. Rep.
4
196-201
2015
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1
1
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731455
Bravo
Design, synthesis and evaluati ...
Homo sapiens
Bioorg. Med. Chem. Lett.
24
4308-4311
2014
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26
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1
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26
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26
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714360
May
Arabidopsis thaliana PECP1 - E ...
Arabidopsis thaliana
Biochim. Biophys. Acta
1824
319-325
2012
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1
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2
1
5
3
2
-
3
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1
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2
1
3
2
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2
1
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1
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1
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2
1
5
3
2
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1
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2
1
3
2
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2
1
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1
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2
2
714357
Beassoni
Site-directed mutations and ki ...
Pseudomonas aeruginosa
Biochim. Biophys. Acta
1814
858-863
2011
-
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1
-
3
-
1
4
-
1
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2
-
4
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4
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3
1
1
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4
1
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1
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3
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1
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4
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1
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2
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4
-
3
1
1
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4
1
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-
1
1
-
4
4
714633
Huesa
PHOSPHO1 is essential for mech ...
Mus musculus
Bone
48
1066-1074
2011
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1
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2
2
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-
714872
Domenech
Phosphorylcholine phosphatase: ...
Pseudomonas aeruginosa
Enzyme Res.
2011
561841
2011
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1
-
1
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5
-
-
3
-
2
-
3
-
1
1
2
-
1
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5
1
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1
1
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1
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1
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5
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3
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2
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1
1
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1
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5
1
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1
1
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2
1
1
2
-
-
714874
Otero
Different effects of Mg2+ and ...
Pseudomonas aeruginosa
Enzyme Res.
2011
918283
2011
-
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1
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9
-
-
4
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1
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2
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2
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1
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1
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1
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9
1
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4
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1
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2
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1
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1
1
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715704
Yadav
Loss of skeletal mineralizatio ...
Mus musculus, Mus musculus C57BL/6
J. Bone Miner. Res.
26
286-297
2011
-
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1
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1
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4
-
3
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3
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4
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4
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3
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4
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2
2
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702538
Otero
Transition from octahedral to ...
Pseudomonas aeruginosa
Biometals
23
307-314
2010
-
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1
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1
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2
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2
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1
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2
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2
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1
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2
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2
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702934
MacRae
Inhibition of PHOSPHO1 activit ...
Gallus gallus
Bone
46
1146-1155
2010
-
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1
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3
-
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706604
Beassoni
Preparation and biophysical ch ...
Pseudomonas aeruginosa
Protein Expr. Purif.
71
153-159
2010
-
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1
1
2
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-
1
-
1
2
-
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5
-
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1
-
1
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1
1
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1
1
1
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1
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1
2
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1
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1
2
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1
1
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1
1
-
-
1
1
1
-
-
-
-
-
-
-
3
3
713654
Otero
Crystallization and preliminar ...
Pseudomonas aeruginosa
Acta Crystallogr. Sect. F
66
957-960
2010
-
-
1
1
-
-
1
-
-
3
2
1
-
2
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1
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1
1
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1
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1
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1
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3
2
1
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1
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1
1
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1
1
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-
696420
Beassoni
Using a molecular model and ki ...
Pseudomonas aeruginosa
Biochim. Biophys. Acta
1784
2038-2044
2008
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1
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4
-
-
14
1
3
-
-
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2
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1
-
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3
1
2
-
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14
-
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1
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4
-
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14
1
3
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1
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3
1
2
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14
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702017
Roberts
Identification of a novel spli ...
Homo sapiens
Biochem. Biophys. Res. Commun.
371
872-876
2008
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1
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3
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1
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1
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-
680993
Roberts
Functional involvement of PHOS ...
Gallus gallus, Homo sapiens, Mus musculus
J. Bone Miner. Res.
22
617-627
2007
1
3
1
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8
-
1
3
1
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5
-
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1
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7
-
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4
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1
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3
-
3
1
3
1
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3
8
3
-
1
3
1
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1
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7
-
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4
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1
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678951
Stewart
The presence of PHOSPHO1 in ma ...
Gallus gallus
Bone
39
1000-1007
2006
1
1
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1
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3
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1
1
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3
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-
679380
Beassoni
Critical active-site residues ...
Pseudomonas aeruginosa
Curr. Microbiol.
53
534-539
2006
1
-
1
-
10
-
-
7
-
1
-
-
-
3
-
-
1
-
-
-
25
1
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
10
-
-
-
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7
-
1
-
-
-
-
-
1
-
-
25
1
2
-
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-
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-
664211
Roberts
Probing the substrate specific ...
Homo sapiens
Biochim. Biophys. Acta
1752
73-82
2005
-
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1
-
5
-
-
-
-
1
-
2
-
2
-
-
1
1
-
-
3
-
3
1
1
-
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1
-
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1
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5
-
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1
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2
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1
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3
-
3
1
1
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-
1
-
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-
-
-
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-
-
664697
Massimelli
Identification, cloning, and e ...
Pseudomonas aeruginosa
Curr. Microbiol.
50
251-256
2005
1
-
1
-
1
-
3
-
1
1
-
2
-
5
-
-
1
-
-
-
1
-
4
-
-
-
-
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2
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