Crystallization (Comment) | Organism |
---|---|
structure in presence of inhibitor [2-[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]ethyl]phosphonic acid. The overall structure of murine PDXP remains unaltered by ligand binding | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
[(E)-2-(4-formyl-5-hydroxy-6-methylpyridin-3-yl)ethenyl]phosphonic acid | compound increases the Km up to 6fold at 2 mM. The catalytic efficiency is reduced to 10% in the presence of 2 mM of the compound | Mus musculus | |
[2-(4-formyl-5-hydroxy-6-methylpyridin-3-yl)ethyl]phosphonic acid | compound increases the Km up to 6fold at 2 mM. The catalytic efficiency is reduced to 10% in the presence of 2 mM of the compound | Mus musculus | |
[2-[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]ethyl]phosphonic acid | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.039 | - |
pyridoxal 5'-phosphate | pH 7.4, 22°C | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P60487 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyridoxal 5'-phosphate + H2O | - |
Mus musculus | pyridoxal + phosphate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
pyridoxal 5'-phosphate | pH 7.4, 22°C | Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.079 | - |
pH 7.4, 22°C | Mus musculus | [2-(4-formyl-5-hydroxy-6-methylpyridin-3-yl)ethyl]phosphonic acid | |
0.246 | - |
pH 7.4, 22°C | Mus musculus | [(E)-2-(4-formyl-5-hydroxy-6-methylpyridin-3-yl)ethenyl]phosphonic acid | |
1.3 | - |
pH 7.4, 22°C | Mus musculus | [2-[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]ethyl]phosphonic acid |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
50 | - |
pyridoxal 5'-phosphate | pH 7.4, 22°C | Mus musculus |