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Literature summary for 3.1.3.74 extracted from

  • Kim, J.E.; Ryu, H.J.; Kim, M.J.; Kim, D.W.; Kwon, O.S.; Choi, S.Y.; Kang, T.C.
    Pyridoxal-5'-phosphate phosphatase/chronophin induces astroglial apoptosis via actin-depolymerizing factor/cofilin system in the rat brain following status epilepticus (2010), Glia, 58, 1937-1948.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyridoxal-5'-phosphate + H2O Rattus norvegicus
-
 pyridoxal + phosphate
-
 ?
pyridoxal-5'-phosphate + H2O Rattus norvegicus Sprague-Dawley
-
 pyridoxal + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Rattus norvegicus
-
astroglia
-
 Rattus norvegicus
-
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyridoxal-5'-phosphate + H2O
-
 Rattus norvegicus pyridoxal + phosphate
-
 ?
pyridoxal-5'-phosphate + H2O
-
 Rattus norvegicus Sprague-Dawley pyridoxal + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PLPP/CIN
-
 Rattus norvegicus
pyridoxal-5'-phosphate phosphatase
-
 Rattus norvegicus
pyridoxal-5'-phosphate phosphatase/chronophin
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function pyridoxal-5'-phosphate phosphatase/chronophin, i.e. PLPP/CIN, regulates phosphorylation of ADF/cofilin levels. PLPP/CIN level show a direct proportionality to nuclear translocation of ADF/cofilin. Nuclear accumulation of ADF/cofilin itself may not induce apoptogenic events, but may play a synergic role in apoptosis-like astroglial loss following status epilepticus, detailed analysis, overview Rattus norvegicus