Literature summary for 3.1.3.7 extracted from

Yenush, L.; Belles, J.M.; Lopez-Coronado, J.M.; Gil-Mascarell, R.; Serrano, R.; Rodriguez, P.L.
A novel target of lithium therapy (2000), FEBS Lett., 467, 321-325.

Search for more literature for 3.1.3.7

Application

Application	Comment	Organism
medicine	enzyme as a potential target of lithium therapy	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
cloning of HsPIP and expression in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Li+	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0004	-	inositol-1,4-bisphosphate	pH 7.5, 30°C	Homo sapiens
0.001	-	adenosine 3',5'-bisphosphate	pH 7.5, 30°C	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required, optimal concentration of 1 mM	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
33000	-	SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
adenosine 3',5'-bisphosphate + H2O	Homo sapiens	the activity of enzyme is required while 3'-phosphoadenosine 5'-phosphate is a potent inhibitor of a variety of enzymes that use 3'-phosphoadenosine 5'-phosphate as cosubstrate	adenosine 5'-phosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O95861	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenosine 2',5'-bisphosphate + H2O	-	Homo sapiens	adenosine 5'-phosphate + phosphate	-	?
adenosine 3',5'-bisphosphate + H2O	-	Homo sapiens	adenosine 5'-phosphate + phosphate	-	?
adenosine 3',5'-bisphosphate + H2O	the activity of enzyme is required while 3'-phosphoadenosine 5'-phosphate is a potent inhibitor of a variety of enzymes that use 3'-phosphoadenosine 5'-phosphate as cosubstrate	Homo sapiens	adenosine 5'-phosphate + phosphate	-	?
inositol-1,4-bisphosphate + H2O	-	Homo sapiens	inositol 4-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
3'(2')-phosphoadenosine 5-phosphate phosphatase	-	Homo sapiens
PAP-phosphatease	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.3	-	Li+	pH 7.5, 30°C, substrate: adenosine 3,5-bisphosphate	Homo sapiens
0.6	-	Li+	pH 7.5, 30°C, substrate: inositol-1,4-bisphosphate	Homo sapiens

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Release 2023.1 (January 2023)