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Literature summary for 3.1.3.67 extracted from

  • Kurokawa, T.; Takasuga, S.; Sakata, S.; Yamaguchi, S.; Horie, S.; Homma, K.J.; Sasaki, T.; Okamura, Y.
    3'Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP) (2012), Proc. Natl. Acad. Sci. USA, 109, 10089-10094.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.67

Cloned(Commentary)

Cloned (Comment) Organism
cytosolic domain (amino acids 215–522) is used for analysis Homo sapiens
cytosolic domain (amino acids 248-576) is used for analysis Ciona intestinalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
 phosphatidylinositol 3,4-bisphosphate pH not specified in the publication, 23°C, Vmax: 0.121 nmol/min/microgram Ciona intestinalis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
cytoplasm
-
 Ciona intestinalis 5737
-

Organism

Organism UniProt Comment Textmining
Ciona intestinalis
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis derived from testis cDNA Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information TLC assay shows that the 3' phosphate of PI(3,4,5)P3 is not dephosphorylated Homo sapiens ?
-
 ?
additional information TLC assay shows that the 3' phosphate of PI(3,4,5)P3 is not dephosphorylated Ciona intestinalis ?
-
 ?
phosphatidylinositol 3,4-bisphosphate + H2O
-
 Homo sapiens phosphatidylinositol 4-phosphate + phosphate
-
 ?
phosphatidylinositol 3,4-bisphosphate + H2O
-
 Ciona intestinalis phosphatidylinositol 4-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
TPIP human VSP ortholog of Ciona intestinalis. Enzyme also possesses 5'-phosphatase activity. Substrate specificity of the VSP changes with membrane potential Homo sapiens
voltage-sensing phosphatase
-
 Ciona intestinalis
VSP enzyme also possesses 5'-phosphatase activity. Substrate specificity of the VSP changes with membrane potential Ciona intestinalis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.12
-
 phosphatidylinositol 3,4-bisphosphate pH not specified in the publication, 23°C, Vmax: 0.121 nmol/min/microgram Ciona intestinalis