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Literature summary for 3.1.3.67 extracted from

  • Langlois, M.J.; Bergeron, S.; Bernatchez, G.; Boudreau, F.; Saucier, C.; Perreault, N.; Carrier, J.C.; Rivard, N.
    The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression (2010), PLoS ONE, 5, e15742.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is activated by the phosphatidylinositol 3-kinase Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information lentiviral infection of PTEN shRNA significantly inhibited Caco-2/15 cell polarization, functional differentiation and brush border development Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the PTEN phosphatase acts on phosphatidylinositol 3,4,5-triphosphates resulting from phosphatidylinositol 3-kinase activation ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is activated by the phosphatidylinositol 3-kinase Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2/15 cell
-
Homo sapiens
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colon
-
Homo sapiens
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colorectal cancer cell decreased enzyme in colorectal cancer Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
intestinal epithelium
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the PTEN phosphatase acts on phosphatidylinositol 3,4,5-triphosphates resulting from phosphatidylinositol 3-kinase activation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PTEN phosphatase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction lentiviral infection of PTEN shRNA significantly inhibits Caco-2/15 cell polarization, functional differentiation and brush border development. A strong reduction in claudin 1, 3, 4 and 8 is also observed as well as a decrease in transepithelial resistance. Loss of PTEN phosphatase expression increases the spreading, migration and invasion capacities of colorectal cancer cells in vitro, role of PTEN in human colorectal cancer cells, phenotype, overview. Loss of PTEN expression in Caco-2/15 cells stimulates migration/invasion, promotes tumor growth but is not sufficient to confer metastatic potential in vivo Homo sapiens
additional information loss of PTEN expression in HCT116 and CT26, but not in Caco-2/15, leads to an increase in their metastatic potential following tail-vein injections in mice Homo sapiens