Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is activated by the phosphatidylinositol 3-kinase | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | lentiviral infection of PTEN shRNA significantly inhibited Caco-2/15 cell polarization, functional differentiation and brush border development | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the PTEN phosphatase acts on phosphatidylinositol 3,4,5-triphosphates resulting from phosphatidylinositol 3-kinase activation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is activated by the phosphatidylinositol 3-kinase | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2/15 cell | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
colorectal cancer cell | decreased enzyme in colorectal cancer | Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
intestinal epithelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the PTEN phosphatase acts on phosphatidylinositol 3,4,5-triphosphates resulting from phosphatidylinositol 3-kinase activation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PTEN phosphatase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | lentiviral infection of PTEN shRNA significantly inhibits Caco-2/15 cell polarization, functional differentiation and brush border development. A strong reduction in claudin 1, 3, 4 and 8 is also observed as well as a decrease in transepithelial resistance. Loss of PTEN phosphatase expression increases the spreading, migration and invasion capacities of colorectal cancer cells in vitro, role of PTEN in human colorectal cancer cells, phenotype, overview. Loss of PTEN expression in Caco-2/15 cells stimulates migration/invasion, promotes tumor growth but is not sufficient to confer metastatic potential in vivo | Homo sapiens |
additional information | loss of PTEN expression in HCT116 and CT26, but not in Caco-2/15, leads to an increase in their metastatic potential following tail-vein injections in mice | Homo sapiens |