Literature summary for 3.1.3.67 extracted from

Wang, Y.; Cheng, A.; Mattson, M.P.
The PTEN phosphatase is essential for long-term depression of hippocampal synapses (2006), Neuromolecular Med., 8, 329-336.

Search for more literature for 3.1.3.67

Application

Application	Comment	Organism
medicine	results demonstrate an important role of PTEN in long term depression and suggest that alterations in PTEN can have an impact on learning and memory process	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	CA1 synapses in hippocampal slices from PTEN-deficient mice exhibit activity-induced long-term potentiation of synaptic transmission but are resistant to long-term depression. PTEN reduces phosphatidylinositol-3-kinase activity and pharmacological inhibition of phosphatidylinositol-3-kinase restores long-term depression of synaptic transmission in PTEN-deficient mice, suggesting that inhibition of phosphatidylinositol-3-kinase is necessary for induction of long term depression	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
PTEN	-	Mus musculus

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Release 2023.1 (January 2023)