Application | Comment | Organism |
---|---|---|
medicine | PTEN plays an important role in insulin-dependent signaling pathways controlling glucose and lipid metabolsim in vivo. A fine tuning of PTEN expression/activation in target organs is likely to be beneficial to correct metabolic dysfunctions in pathological conditions such as insulin resistance diabetes melitus and obesity | Mus musculus |
Cloned (Comment) | Organism |
---|---|
overexpressed in 3T3L1 adipocytes | Mus musculus |
overexpressed in MCF-7 breast cancer cell line | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | adipose tissue-specific depletion of PTEN in mice results in improved glucose tolerance and insulin sensitivity rendering mice resistant to streptozotocin-induced diabetes. Increased recruitment of Glut4 transporters at the plasma membrane of adipocytes,whereas the contrary is observed in muscle of the same animals. Decreased expression of resistin is shown | Mus musculus |
additional information | deletion of one PTEN allele in insulin receptor substrate 2 (IRS2) in mice is able to restore pancreatic beta-cell function, peripheral insulin sensitivity, glucose tolerance and significantly increases life span of the animals, indicating that PTEN controls insulin sensitivity in peripheral tissues and pancreatic beta-cell growth and function | Mus musculus |
additional information | liver-specific deletion of PTEN in mice results in enhanced insulin sensitivity, hypoinsulinemia, hypoleptinemia and overall improved glucose tolerance. Adult mice lacking PTEN in liver also develop hepatomegaly syndromes, steatohepatitis and hepatocellular carcinomas | Mus musculus |
additional information | muscle-specific depletion of PTEN in mice results in improved glucose metabolism in animals with diabetes and insulin resistance. Elevated fasting glucose levels are prevented and insulin sensitivity and glucose tolerance in high-fat fed animals are improved. Insulin stimulated Akt-activation is enhanced. PTEN depletion in muscle is not associated with increased tumorigenesis | Mus musculus |
additional information | overexpresion of catalytically inactive or dominant-negative PTEN mutants in 3T1-L1 adipocytes show that it is the lipid phosphatase activity of PTEN which is required to downregulate Akt/PKB signaling and glucose uptake in response to insulin | Mus musculus |
additional information | PTEN downregulation in 3T1-L1 adipocytes by small interfering RNAs enhances Akt/PKB activation and glucose uptake in response to insulin | Mus musculus |
additional information | PTEN null mutations in mice are lethal at embryonic stages and even a 50% reduction in PTEN expression leads to increased tumorigenesis | Mus musculus |
additional information | PTEN overexpression in 3T1-L1 adipocytes causes inhibition of insulin-induced PtdIns(3,4)P2 and PtdIns(3,4,5)P3 production, Akt/PKB activation, GLUT4 translocation to the cell membrane and glucose uptake | Mus musculus |
additional information | PTEN overexpression in MCF-7 breast cancer cell line prevents ERK1/2 phosphorylation in response to insulin. Inhibition of ERK1/2 activation is not only caused by a reduction in PtdIns(3,4,5)P3 level but also by a decreased association of Shc with Grb2/Sos complex and Ras activation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Mus musculus | - |
breast cancer cell line | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | - |
Mus musculus | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate | - |
? | |
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate | - |
? | |
phosphatidylinositol 3,4-bisphosphate + H2O | - |
Mus musculus | phosphatidylinositol 4-phosphate + phosphate | - |
? | |
phosphatidylinositol 3,4-bisphosphate + H2O | - |
Homo sapiens | phosphatidylinositol 4-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PTEN | - |
Mus musculus |
PTEN | - |
Homo sapiens |