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Literature summary for 3.1.3.67 extracted from

  • Ramaswamy, S.; Nakamura, N.; Vazquez, F.; Batt, D.B.; Perera, S.; Roberts, T.M.; Sellers, W.R.
    Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway (1999), Proc. Natl. Acad. Sci. USA, 96, 2110-2115.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
C124S catalytically inert mutant enzyme Homo sapiens
D92A catalytically inert mutant enzyme, retains partial ability to induce cells to accumulate in G1 Homo sapiens
G129E mutant enzyme associated with Cowden‘s disease has protein phosphatase activity yet is defective in dephosphorylating inositol 1,3,4,5-tetrakisphosphate in vitro and fails to arrest cells in G1 Homo sapiens
G129R the enzyme fails to induce a G1 block Homo sapiens
PTEN1-274 when produced as glutathione S-transferase fusion protein, the protein is defective in catalyzing the release of phosphate from either a phosphate-labeled poly(Glu4-Tyr1) substrate or inositol 1,3,4,5-tetrakisphosphate Homo sapiens
PTEN1-336 when produced as glutathione S-transferase fusion protein, the protein is defective in catalyzing the release of phosphate from either a phosphate-labeled poly(Glu4-Tyr1) substrate or inositol 1,3,4,5-tetrakisphosphate Homo sapiens
PTENDELTA274-342 when produced as glutathione S-transferase fusion protein, the protein is defective in catalyzing the release of phosphate from either a phosphate-labeled poly(Glu4-Tyr1) substrate or inositol 1,3,4,5-tetrakisphosphate Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PTEN might regulate cell-cycle progression by blocking activation of downstream targets of phosphatidylinositol 3-kinase such as the protooncogene Akt. PTEN is capable of inhibiting wild-type Akt kinase activity in cells ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PTEN might regulate cell-cycle progression by blocking activation of downstream targets of phosphatidylinositol 3-kinase such as the protooncogene Akt. PTEN is capable of inhibiting wild-type Akt kinase activity in cells Homo sapiens ?
-
 ?