General Stability | Organism |
---|---|
the 50-amino-acid C-terminal domain, the tail, is necessary for maintaining protein stability | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol 3,4,5-trisphosphate + H2O | Homo sapiens | tumor suppressor function. Dephosphorylation of the second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway | phosphatidyl inositol 4,5-bisphosphate + phosphate | - |
? | |
phosphatidylinositol-3,4-bisphosphate + H2O | Homo sapiens | tumor suppressor function. Dephosphorylation of the second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway | phosphatidylinositol 4-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the 50-amino-acid C-terminal domain, the tail, is necessary for maintaining protein stability and it also acts to inhibit PTEN function. The tail-dependent regulation of stability and activity is linked to the phosphorylation of three residues, S380, T382, and T383 within the tail. Therefor, the tail is likely to mediate the regulation of PTEN function through phosphorylation | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol 3,4,5-trisphosphate + H2O | tumor suppressor function. Dephosphorylation of the second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway | Homo sapiens | phosphatidyl inositol 4,5-bisphosphate + phosphate | - |
? | |
phosphatidylinositol 3,4-bisphosphate + H2O | tumor suppressor function. Dephosphorylation of the second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway | Homo sapiens | phosphatidylinositol 4-phosphate + phosphate | - |
? | |
phosphatidylinositol-3,4-bisphosphate + H2O | tumor suppressor function. Dephosphorylation of the second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway | Homo sapiens | phosphatidylinositol 4-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PTEN | - |
Homo sapiens |