Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.67 extracted from

  • Vazquez, F.; Ramaswamy, S.; Nakamura, N.; Sellers, W.R.
    Phosphorylation of the PTEN tail regulates protein stability and function (2000), Mol. Cell. Biol., 20, 5010-5018.
    View publication on PubMedView publication on EuropePMC

General Stability

General Stability Organism
the 50-amino-acid C-terminal domain, the tail, is necessary for maintaining protein stability Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylinositol 3,4,5-trisphosphate + H2O Homo sapiens tumor suppressor function. Dephosphorylation of the second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway phosphatidyl inositol 4,5-bisphosphate + phosphate
-
?
phosphatidylinositol-3,4-bisphosphate + H2O Homo sapiens tumor suppressor function. Dephosphorylation of the second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway phosphatidylinositol 4-phosphate + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the 50-amino-acid C-terminal domain, the tail, is necessary for maintaining protein stability and it also acts to inhibit PTEN function. The tail-dependent regulation of stability and activity is linked to the phosphorylation of three residues, S380, T382, and T383 within the tail. Therefor, the tail is likely to mediate the regulation of PTEN function through phosphorylation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylinositol 3,4,5-trisphosphate + H2O tumor suppressor function. Dephosphorylation of the second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway Homo sapiens phosphatidyl inositol 4,5-bisphosphate + phosphate
-
?
phosphatidylinositol 3,4-bisphosphate + H2O tumor suppressor function. Dephosphorylation of the second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway Homo sapiens phosphatidylinositol 4-phosphate + phosphate
-
?
phosphatidylinositol-3,4-bisphosphate + H2O tumor suppressor function. Dephosphorylation of the second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway Homo sapiens phosphatidylinositol 4-phosphate + phosphate
-
?

Synonyms

Synonyms Comment Organism
PTEN
-
Homo sapiens