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Literature summary for 3.1.3.67 extracted from

  • Hlobilkova, A.; Guldberg, P.; Thullberg, M.; Zeuthen, J.; Lukas, J.; Bartek, J.
    Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity (2000), Exp. Cell Res., 256, 571-577.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
G129E mutant enzyme is selectively deficient in the lipid phosphatase activity but still blocks the cell cycle of MCF-7 cells Homo sapiens
H123Y mutant enzyme lacking phosphatase activity is ineffective in blocking the cell cycle of MCF-7 cells Homo sapiens
H129R mutant enzyme lacking phosphatase activity is ineffective in blocking the cell cycle of MCF-7 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens protein phosphatase activity may contribute to the cell cycle inhibitory and thereby tumor suppresive function of PTEN ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell line
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information protein phosphatase activity may contribute to the cell cycle inhibitory and thereby tumor suppresive function of PTEN Homo sapiens ?
-
 ?