Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.66 extracted from

  • Nigorikawa, K.; Hazeki, K.; Sasaki, J.; Omori, Y.; Miyake, M.; Morioka, S.; Guo, Y.; Sasaki, T.; Hazeki, O.
    Inositol polyphosphate-4-phosphatase type I negatively regulates phagocytosis via dephosphorylation of phagosomal PtdIns(3,4)P2 (2015), PLoS ONE, 10, e0142091 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.66

Organism

Organism UniProt Comment Textmining
Mus musculus Q9EPW0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
-
 Mus musculus
-

General Information

General Information Comment Organism
physiological function Raw264.7 cells that express shRNA against isoform Inpp4a show significantly increased phagocytic activity. Macrophages from Inpp4a knockout mice show similar increases in the phagocytic activity. Inpp4a is recruited to the phagosome membrane by a mechanism other than the direct interaction with Rab5. The level of PtdIns(3,4)P2 increases on the phagosome of shRNA-treated cells, while the level of PtdIns(3)P significantly decreases Mus musculus