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Literature summary for 3.1.3.66 extracted from

  • Li, H.; Wu, X.; Hou, S.; Malek, M.; Kielkowska, A.; Noh, E.; Makondo, K.J.; Du, Q.; Wilkins, J.A.; Johnston, J.B.; Gibson, S.B.; Lin, F.; Marshall, A.J.
    Phosphatidylinositol-3,4-bisphosphate and its binding protein lamellipodin regulate chemotaxis of malignant B lymphocytes (2016), J. Immunol., 196, 586-595 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens O15327
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Source Tissue

Source Tissue Comment Organism Textmining
B-cell from chronic lymphocytic leukemia patients Homo sapiens
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RAJI cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function cells expressing wild-type, but not catalytically inactive inositol polyphosphate 4-phosphatase show impaired phosphatidylinositol-3,4-bisphosphate responses induced by chenomkine SDF-1 and reduced migration in Transwell chamber assays. Phosphatidylinositol-3,4-bisphosphate depletion in primary chronic lymphocytic leukemia cells significantly impairs their migration capacity. Phosphatidylinositol-3,4-bisphosphate depletion reduces both overall motility and migration directionality in the presence of a stable chemokine gradient Homo sapiens