Literature summary for 3.1.3.66 extracted from

Rijal, S.; Fleming, S.; Cummings, N.; Rynkiewicz, N.K.; Ooms, L.M.; Nguyen, N.Y.; Teh, T.C.; Avery, S.; McManus, J.F.; Papenfuss, A.T.; McLean, C.; Guthridge, M.A.; Mitchell, C.A.; Wei, A.H.
Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML (2015), Blood, 125, 2815-2824 .

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Application

Application	Comment	Organism
medicine	in acute myeloid leukemia, isoform IPNPP4B is significantly overexpressed, in association with reduced responses to chemotherapy, early relapse, and poor overall survival, independent of other risk factors. Ectopic overexpression of INPP4B confers leukemic resistance to cytosine arabinoside, daunorubicin, and etoposide. Expression of phosphatase inert variant C842A fails to abrogate resistance of acute myeloid leukemiacells to chemotherapy in vitro or in vivo. Targeted suppression of endogenously overexpressed INPP4B by RNAi sensitizes acute myeloid leukemia cell lines and primary acute myeloid leukemia to chemotherapy	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C842A	loss of catalytic activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15327	-	-

Synonyms

Synonyms	Comment	Organism
INPP4B	-	Homo sapiens

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Release 2023.1 (January 2023)