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Literature summary for 3.1.3.66 extracted from

  • Khanna, K.; Chaudhuri, R.; Aich, J.; Pattnaik, B.; Panda, L.; Prakash, Y.S.; Mabalirajan, U.; Ghosh, B.; Agrawal, A.
    Secretory inositol polyphosphate 4-phosphatase protects against airway inflammation and remodeling (2018), Am. J. Respir. Cell Mol. Biol., 60, 399-412 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
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 Homo sapiens
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-
extracellular
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 Mus musculus
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-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96PE3
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Mus musculus Q9EPW0
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-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium airway epithelial cell Homo sapiens
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epithelium airway epithelial cell Mus musculus
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Synonyms

Synonyms Comment Organism
INPP4A
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 Homo sapiens
INPP4A
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 Mus musculus

General Information

General Information Comment Organism
physiological function INPP4a is secreted by airway epithelial cells and extracellular INPP4A critically inhibits airway inflammation and remodeling. INPP4A is present in blood and broncho-alveolar lavage fluid and is reduced in asthma patients. Cultured airway epithelial cells secrete enzymatically active INPP4A in extracellular vesicles and in a free form. Extracellular vesicles-mediated INPP4A is transferred from epithelial cells to fibroblasts. Inhibition of this transfer increases fibroblast proliferation Homo sapiens
physiological function INPP4a is secreted by airway epithelial cells and extracellular INPP4A critically inhibits airway inflammation and remodeling. INPP4A is present in blood and broncho-alveolar lavage fluid and is reduced in mice with allergic airway inflammation. In mice with allergic airway inflammation as well as naive mice, antibody-mediated neutralization of extracellular INPP4A potentiates PI3K/Akt signaling and induces airway hyperresponsiveness, with prominent airway remodeling, sub-epithelial fibroblast proliferation and collagen deposition Mus musculus