Literature summary for 3.1.3.66 extracted from

Fedele, C.G.; Ooms, L.M.; Ho, M.; Vieusseux, J.; OToole, S.A.; Millar, E.K.; Lopez-Knowles, E.; Sriratana, A.; Gurung, R.; Baglietto, L.; Giles, G.G.; Bailey, C.G.; Rasko, J.E.; Shields, B.J.; Price, J.T.; Majerus, P.W.; Sutherland, R.L.; Tiganis, T.; McLean, C.A.; Mitchell, C.A.
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers (2010), Proc. Natl. Acad. Sci. USA, 107, 22231-22236.

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue	Comment	Organism	Textmining
breast cancer cell	primary, the enzyme is expressed in nonproliferative estrogen receptor-positive cells in the normal breast, and in estrogen receptor-positive, but not negative, breast cancer cell lines	Homo sapiens	-
BT-474 cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
additional information	INPP4B protein expression is frequently lost in primary human breast carcinomas, associated with high clinical grade and tumor size and loss of hormone receptors and is lost most commonly in aggressive basal-like breast carcinomas	Homo sapiens	-
additional information	no expression in MDA MB 231 cells, Hs578T cells, and BT-549cells. Colocalization of INPP4B and the proliferation marker, Ki-67, in breast lobules	Homo sapiens	-
T-47D cell	-	Homo sapiens	-

Synonyms	Comment	Organism
inositol polyphosphate 4-phosphatase II	-	Homo sapiens
INPP4B	-	Homo sapiens

General Information	Comment	Organism
malfunction	inositol polyphosphate 4-phosphatase-II knockdown in estrogen receptor-positive breast cancer cells increased Akt activation, cell proliferation, and xenograft tumor growth	Homo sapiens
physiological function	quantitative real-time reverse-transcription PCR analysis, inositol polyphosphate 4-phosphatase-II , INPP4B, functions as a tumor suppressor by negatively regulating normal and malignant mammary epithelial cell proliferation through regulation of the PI3K/Akt signaling pathway, and that loss of INPP4B protein is a marker of aggressive basal-like breast carcinomas	Homo sapiens