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Literature summary for 3.1.3.66 extracted from

  • Sachs, A.; David, S.; Haider, N.; Nystuen, A.
    Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4 (2009), PLoS ONE, 4, e8270.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
cerebellar Purkinje cell restricted to the Purkinje cell soma and their dendrites in the molecular layer Mus musculus
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cerebellum
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 Mus musculus
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Synonyms

Synonyms Comment Organism
inositol polyphosphate 4-phosphatase type I
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 Mus musculus
INPP4A
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus expression of INPP4A is uniform across the cerebellum and the Purkinje cells up

General Information

General Information Comment Organism
malfunction Inpp4a weeble mutant has a frame shift mutation in Inpp4a and is characterized by an early onset recessive cerebellar ataxia. In the Inpp4a weeble mutant, Purkinje cells are lost in a specific temporal and spatial pattern: Purkinje cells are lost at early perinatal timepoints. Prior to the appearance of climbing fibers in the developing molecular layer, the Inpp4a weeble mutant has a normal complement of Purkinje cells and they are properly positioned, degeneration and reactive gliosis are present at postnatal day 5 and progress rapidly in a defined pattern of patches. Purkinje cell loss in the Inpp4awbl mutant is due to glutamate excitotoxicity initiated by the climbing fiber, whereby Eaat4 may exert a protective effect Mus musculus