Cloned (Comment) | Organism |
---|---|
full-length 4-ptase-1 cDNA subcloned into the EcoRI site of pWzl-Hygromycin vector | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic fibroblast cell line | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
4-ptase-1 | - |
Mus musculus |
inositol polyphosphate 4-phosphatase-1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | level of 4-ptase-1 protein expressed in reconstituted embryonic fibroblasts reveals a 5fold increase relative to endogenous 4-ptase-1 in +/+MEFs | up |
General Information | Comment | Organism |
---|---|---|
malfunction | in mouse embryonic fibroblasts lacking 4-ptase-1 (-/-MEFs), the Akt-pleckstrin homology domain is constitutively membrane-associated both in serum-starved and agonist-stimulated cells. 4-Ptase-1-deficient cells show increased Akt signalling. Loss of 4-ptase-1 results in increased cell proliferation and decreased apoptosis. Loss of function of 4-ptase-1 leads to increased and sustained growth factor-stimulated levels of pSer473/Thr308-Akt and Akt phospho-substrates | Mus musculus |
physiological function | 4-ptase-1 controls the activation of Akt and thereby cell proliferation, survival and tumorigenesis. In mouse embryonic fibroblasts (+/+MEFs), the Akt-pleckstrin homology domain is detected at the plasma membrane following serum stimulation | Mus musculus |