Literature summary for 3.1.3.64 extracted from

Cao, C.; Laporte, J.; Backer, J.M.; Wandinger-Ness, A.; Stein, M.P.
Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes (2007), Traffic, 8, 1052-1067.

Search for more literature for 3.1.3.64

Cloned(Commentary)

Cloned (Comment)	Organism
expressed as an N-terminal FLAG-tagged fusion construct	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C375S	a phosphatase-dead mutant of MTM1 also localizes in early and late endosomes	Homo sapiens
additional information	loss of endosomal phosphatidylinositol 3-phosphate upon overexpression of wild-type MTM1, but not a phosphatase-dead MTM1C375S mutant, results in altered early and late endosomal phosphatidylinositol 3-phosphate levels and rapid depletion of early endosome antigen-1	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endosome	MTM1 localizes to both early and late endosomes and associates with the hVPS15/hVPS34 complex. Both Rab7 and MTM1 bind to hVPS15, the hVPS34 adapter molecule that regulates hVPS34 activity through its interactions with Rab5 and Rab7. The WD40 domain of hVPS15 mediates binding to Rab5, Rab7 and MTM1. Consequently, binding of the hVPS15/hVPS34 complex to the Rab GTPases and MTM1 is mutually exclusive	Homo sapiens	5768	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
MTM1	-	Homo sapiens
myotubular myopathy 1 PI 3-phosphatase	-	Homo sapiens
myotubularin	-	Homo sapiens

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Release 2023.1 (January 2023)