Literature summary for 3.1.3.64 extracted from

Choudhury, P.; Srivastava, S.; Li, Z.; Ko, K.; Albaqumi, M.; Narayan, K.; Coetzee, W.A.; Lemmon, M.A.; Skolnik, E.Y.
Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain (2006), J. Biol. Chem., 281, 31762-31769.

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Protein Variants

Protein Variants	Comment	Organism
additional information	MTMR6 specifically inhibits the Ca2+-activated K+ channel, KCa3.1, by dephosphorylating phosphatidylinositol-3-phosphate. Chimeric MTMs containing both the MTMR6 coiled-coil (CC)(aa 512-621) and pleckstrin homology/GRAM (PH/G) (aa 1-106) domains function like MTMR6 to inhibit KCa3.1 channel activity, whereas chimeric MTMs containing either domain alone do not	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	immunofluorescent microscopy demonstrate that both the MTMR6 coiled-coil (CC)(aa 512-621) and pleckstrin homology/GRAM (PH/G) (aa 1-106) domains are required to co-localize MTMR6 to the plasma membrane with KCa3.1	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
MTM	-	Homo sapiens
MTMR6	-	Homo sapiens
myotubularin	-	Homo sapiens

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Release 2023.1 (January 2023)