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Literature summary for 3.1.3.64 extracted from

  • Robinson, F.L.; Dixon, J.E.
    The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-tooth disease (2005), J. Biol. Chem., 280, 31699-31707.
    View publication on PubMed
Search for more literature for 3.1.3.64

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence analysis, phylogenetic analysis, coexpression of FLAG-tagged MTMR2 and MTMR13 in HEK-293A cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information MTMR13-defective mutant cells show altered subcellular distribution of enzyme MTMR2 in the cytoplasmic and microsomal fraction Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome membranes of late endosome, MTMR2-MTMR13 complex Homo sapiens 5768
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lysosome membranes Homo sapiens 5764
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membrane associated, MTMR2-MTMR13 complex Homo sapiens 16020
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additional information the enzyme associates with membranes where substrates are localized mediated by membrane-associated pseudophosphatase MTMR13, overview Homo sapiens
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol + phosphate
-
 ?
additional information Homo sapiens MTMR2, a phosphoinositide-3-phosphatase, associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-tooth disease ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13614
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol + phosphate
-
 ?
additional information MTMR2, a phosphoinositide-3-phosphatase, associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-tooth disease Homo sapiens ?
-
 ?
additional information analysis of binding between recombinant MTMR2 and MTMR13, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MTMR2
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 Homo sapiens
myotubularin-related 2
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 Homo sapiens
phosphoinositide-3-phosphatase
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 Homo sapiens