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Literature summary for 3.1.3.62 extracted from
- Comparison of the activities of a multiple inositol polyphosphate phosphatase obtained from several sources: a search for heterogeneity in this enzyme (1995), Biochem. J., 305, 491-498.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Inositol 1,3,4,5,6-pentakisphosphate | - |
Rattus norvegicus |  |
| Inositol hexakisphosphate | - |
Rattus norvegicus | |
| additional information | extracts of liver, heart, kidney, testis and brain contain different amounts of endogenous inhibitors of enzyme activity | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | liver enzyme, inside, approximately evenly distributed between the rough and smooth subfractions | Rattus norvegicus | 5783 | - |
| particle-bound | liver enzyme | Rattus norvegicus | - |
- |
| plasma membrane | erythrocytes | Meleagris gallopavo | 5886 | - |
| plasma membrane | erythrocytes | Rattus norvegicus | 5886 | - |
| soluble | liver enzyme | Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
gel filtration | Rattus norvegicus |
| 36000 | - |
liver enzyme | Rattus norvegicus |
| 47000 | - |
1 * 47000, liver enzyme, doublet, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | function is unrelated to the metabolism of Ca2+-mobilizing cellular signals | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Meleagris gallopavo | - |
- |
- |
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 22400fold from liver | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | lowest specific activity | Rattus norvegicus | - |
| erythrocyte | plasma membrane | Meleagris gallopavo | - |
| erythrocyte | plasma membrane | Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | highest specific activity | Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
| 4.29 | - |
pH 7.4, liver enzyme | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 20% v/v glycerol, 1 mg/ml bovine serum albumin, up to 12 months, stable | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | - |
Rattus norvegicus | D-myo-inositol 1,4,5-trisphosphate + phosphate | - |
? | |
| additional information | function is unrelated to the metabolism of Ca2+-mobilizing cellular signals | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 47000, liver enzyme, doublet, SDS-PAGE | Rattus norvegicus |
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