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Literature summary for 3.1.3.6 extracted from

  • Guimaraes-Costa, A.B.; DeSouza-Vieira, T.S.; Paletta-Silva, R.; Freitas-Mesquita, A.L.; Meyer-Fernandes, J.R.; Saraiva, E.M.
    3-nucleotidase/nuclease activity allows Leishmania parasites to escape killing by neutrophil extracellular traps (2014), Infect. Immun., 82, 1732-1740.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine enzyme displays higher activity in parasites cultured in low phosphate medium. Both promastigotes grown in low or high phosphate medium are capable of inducing the release of neutrophil extracellular traps from human neutrophils in a dose- and time-dependent manner. Parasites grown in low phosphate have 2.4 times higher survival rate than high phosphate promastigotes. Neutrophil extracellular traps disruption is prevented by the treatment of the parasites with inhibitor ammonium tetrathiomolybdate. Inhibition of the enzyme by 3'-AMP, 5'-GMP, or ammonium tetrathiomolybdate decreases promastigote survival upon interaction with neutrophils Leishmania infantum

Organism

Organism UniProt Comment Textmining
Leishmania infantum
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-
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Source Tissue

Source Tissue Comment Organism Textmining
promastigote
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 Leishmania infantum
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General Information

General Information Comment Organism
physiological function enzyme displays higher activity in parasites cultured in low phosphate medium. Both promastigotes grown in low or high phosphate medium are capable of inducing the release of neutrophil extracellular traps from human neutrophils in a dose- and time-dependent manner. Parasites grown in low phosphate have 2.4 times higher survival rate than high phosphate promastigotes. Neutrophil extracellular traps disruption is prevented by the treatment of the parasites with inhibitor ammonium tetrathiomolybdate. Inhibition of the enzyme by 3'-AMP, 5'-GMP, or ammonium tetrathiomolybdate decreases promastigote survival upon interaction with neutrophils Leishmania infantum