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Literature summary for 3.1.3.6 extracted from
- A unique surface membrane anchored purine-salvage enzyme is conserved among a group of primitive eukaryotic human pathogens (2001), Mol. Cell. Biochem., 220, 109-116.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | surface membrane anchored enzyme | Trypanosoma brucei | 16020 | - |
| membrane | surface membrane anchored enzyme | Crithidia fasciculata | 16020 | - |
| membrane | surface membrane anchored enzyme | Leishmania donovani | 16020 | - |
| membrane | surface membrane anchored enzyme | Leishmania mexicana | 16020 | - |
| membrane | surface membrane anchored enzyme | Crithidia luciliae | 16020 | - |
| membrane | surface membrane anchored enzyme | Leishmania major | 16020 | - |
| membrane | surface membrane anchored enzyme | Leishmania infantum | 16020 | - |
| membrane | surface membrane anchored enzyme | Leishmania tropica | 16020 | - |
| membrane | surface membrane anchored enzyme | Leptomonas seymouri | 16020 | - |
| membrane | surface membrane anchored enzyme | Phytomonas serpens | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
x * 40000, SDS-PAGE | Leishmania mexicana |
| 43000 | - |
x * 43000, SDS-PAGE | Leishmania tropica |
| 43000 | - |
x * 43000, strain 1S-CL2D and strain WR657, SDS-PAGE | Leishmania donovani |
| 43000 | - |
x * 43000, strain WR662, strain LV39/CC.1 and strain Friedlin, SDS-PAGE | Leishmania major |
| 43000 | - |
x * 43000, strain, SDS-PAGE | Leishmania infantum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Leishmania donovani | the enzyme is involved in salvage of host-derived purines, which are essential for the survival of the parasite | ? | - |
? |  |
| additional information | Trypanosoma brucei | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
| additional information | Crithidia fasciculata | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
| additional information | Leishmania mexicana | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
| additional information | Crithidia luciliae | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
| additional information | Leishmania major | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
| additional information | Leishmania infantum | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
| additional information | Leishmania tropica | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
| additional information | Leptomonas seymouri | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
| additional information | Leishmania mexicana M379 | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
| additional information | Leishmania infantum FVM1001JL | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
| additional information | Leishmania tropica WR664 | the enzyme must play a critical role in purine salvage of the human pathogen | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Crithidia fasciculata | - |
ATCC 50083 | - |
| Crithidia luciliae | - |
ATCC 30258 | - |
| Leishmania donovani | - |
strain 1S-CL2D, strain WR657, strain WR684 | - |
| Leishmania infantum | - |
- |
- |
| Leishmania infantum FVM1001JL | - |
- |
- |
| Leishmania major | - |
strain WR662, strain LV39/CC.1 and strain Friedlin | - |
| Leishmania mexicana | - |
- |
- |
| Leishmania mexicana M379 | - |
- |
- |
| Leishmania tropica | - |
and strain WR683 | - |
| Leishmania tropica WR664 | - |
and strain WR683 | - |
| Leptomonas seymouri | - |
ATCC 30220 | - |
| Phytomonas serpens | - |
very low activity | - |
| Phytomonas serpens TCC/USP | - |
very low activity | - |
| Trypanosoma brucei | - |
strain EATRO Lab:110 and strain MI427 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-AMP + H2O | - |
Trypanosoma brucei | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Crithidia fasciculata | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Leishmania donovani | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Leishmania mexicana | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Crithidia luciliae | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Leishmania major | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Leishmania infantum | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Leishmania tropica | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Leptomonas seymouri | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Phytomonas serpens | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Leishmania mexicana M379 | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Leishmania infantum FVM1001JL | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Leishmania tropica WR664 | adenosine + phosphate | - |
? | |
| 3'-AMP + H2O | - |
Phytomonas serpens TCC/USP | adenosine + phosphate | - |
? | |
| additional information | the enzyme is involved in salvage of host-derived purines, which are essential for the survival of the parasite | Leishmania donovani | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Trypanosoma brucei | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Crithidia fasciculata | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Leishmania mexicana | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Crithidia luciliae | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Leishmania major | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Leishmania infantum | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Leishmania tropica | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Leptomonas seymouri | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Leishmania mexicana M379 | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Leishmania infantum FVM1001JL | ? | - |
? | |
| additional information | the enzyme must play a critical role in purine salvage of the human pathogen | Leishmania tropica WR664 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 43000, SDS-PAGE | Leishmania tropica |
| ? | x * 40000, SDS-PAGE | Leishmania mexicana |
| ? | x * 43000, strain 1S-CL2D and strain WR657, SDS-PAGE | Leishmania donovani |
| ? | x * 43000, strain WR662, strain LV39/CC.1 and strain Friedlin, SDS-PAGE | Leishmania major |
| ? | x * 43000, strain, SDS-PAGE | Leishmania infantum |
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Release 2023.1 (January 2023)
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