Cloned (Comment) | Organism |
---|---|
expression of His-tagged enzyme in Escherichia coli strain JM109 | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein PRIP-1 | binding to PRIP-1, a Ins(1,4,5)P3-binding protein, inhibits the enzyme in vitro, in vivo binding of Ins(1,4,5)P3 to PRIP-1 prevents it from being hydrolyzed by the enzyme, PRIP-1 has a domain organization similar to phospholipase C-delta1, interaction analysis, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | associated | Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | dependent on | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
48000 | - |
x * 48000, recombinant His-tagged enzyme, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1D-myo-inositol 1,4,5-trisphosphate + H2O | Mus musculus | the enzyme is involved in Ins(1,4,5)P3-mediated Ca2+ signaling associated to PRIP-1, a Ins(1,4,5)P3-binding protein, overview | 1D-myo-inositol 1,4-bisphosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Mus musculus | - |
brain | - |
Mus musculus | - |
neuron | cortical | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Mus musculus | 1D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
1D-myo-inositol 1,4,5-trisphosphate + H2O | the enzyme is involved in Ins(1,4,5)P3-mediated Ca2+ signaling associated to PRIP-1, a Ins(1,4,5)P3-binding protein, overview | Mus musculus | 1D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
additional information | the enzyme binds to PRIP-1, a Ins(1,4,5)P3-binding protein, via the protein's PH-domain, which inhibits the enzyme activity | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 48000, recombinant His-tagged enzyme, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
5PTaseI | - |
Mus musculus |
inositol polyphosphate 5-phosphatase | - |
Mus musculus |