Cloned (Comment) | Organism |
---|---|
expressed in COS-7 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
DELTA1-119 | no significant influence on localization of enzyme | Rattus norvegicus |
DELTA1-311 | no significant influence on localization of enzyme | Rattus norvegicus |
DELTA1-433 | enzyme mainly in cytoplasm | Rattus norvegicus |
DELTA725-1001 | enzyme exclusively cytoplasmic | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | ruffling membranes | Rattus norvegicus | 16020 | - |
membrane | two isoforms postulated one of which is membrane associated | Rattus norvegicus | 16020 | - |
soluble | two isoforms postulated one of which is soluble | Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
107000 | - |
calculated molecular mass, found to be slightly larger in SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O | Rattus norvegicus | regulation of the 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate level at membrane ruffels | phosphatidylinositol 4-phosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | Rattus norvegicus | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | cytoplasmic enzyme highly phosphorylated | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | PIPP enzyme | Rattus norvegicus | - |
heart | PIPP enzyme | Rattus norvegicus | - |
kidney | PIPP enzyme | Rattus norvegicus | - |
liver | isoform of PIPP enzyme | Rattus norvegicus | - |
lung | PIPP enzyme | Rattus norvegicus | - |
additional information | PIPP enzyme not expressed in spleen, thymus, skeletal muscle, testis and skin | Rattus norvegicus | - |
small intestine | PIPP enzyme | Rattus norvegicus | - |
stomach | PIPP enzyme | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O | - |
Rattus norvegicus | phosphatidylinositol 4-phosphate + phosphate | - |
? | |
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O | regulation of the 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate level at membrane ruffels | Rattus norvegicus | phosphatidylinositol 4-phosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Rattus norvegicus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
proline-rich inositol polyphosphate 5-phosphatase | PIPP | Rattus norvegicus |