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Literature summary for 3.1.3.56 extracted from

  • Hansbro, P.M.; Foster, P.S.; Hogan, S.P.; Ozaki, S.; Denborough, M.A.
    Purification and characterization of D-myo-inositol (1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase from skeletal muscle (1994), Arch. Biochem. Biophys., 311, 47-54.
    View publication on PubMed
Search for more literature for 3.1.3.56

Inhibitors

Inhibitors Comment Organism Structure
2,3-bisphosphoglycerate
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0011
-
 D-myo-Inositol 1,3,4,5-tetrakisphosphate type I enzyme, pH 7.5, 37°C Sus scrofa
0.0089
-
 D-myo-inositol 1,4,5-trisphosphate type I enzyme, pH 7.5, 37°C Sus scrofa
0.0714
-
 D-myo-inositol 1,4,5-trisphosphate type II enzyme, pH 7.5, 37°C Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Sus scrofa 16020
-
soluble 83% of total activity Sus scrofa
-
-
soluble two different soluble enzymes, type I and type II Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
 SDS-PAGE, type I enzyme Sus scrofa
81000
-
 gel filtration, type II enzyme Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Sus scrofa
-
 D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O Sus scrofa involved in regulation of excitation-contraction coupling in skeletal muscle D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O Sus scrofa regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
type I enzyme Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
muscle skeletal muscle Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.54
-
 purified type I enzyme, pH 7.5, 37°C Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Sus scrofa D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O type I and type II enzyme Sus scrofa D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Sus scrofa D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O involved in regulation of excitation-contraction coupling in skeletal muscle Sus scrofa D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Sus scrofa D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?