Application | Comment | Organism |
---|---|---|
medicine | potential target for drugs | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-chiro-Inositol 1,4,6-trisphosphorothioate | very potent inhibitor | Homo sapiens | |
L-chiro-Inositol 1,4,6-trisphosphorothioate | very potent inhibitor | Rattus norvegicus | |
L-chiro-Inositol 2,3,5-trisphosphorothioate | very potent inhibitor | Homo sapiens | |
L-chiro-Inositol 2,3,5-trisphosphorothioate | very potent inhibitor | Rattus norvegicus | |
L-myo-inositol 1,3,5-trisphosphorothioate | very potent inhibitor | Homo sapiens | |
L-myo-inositol 1,3,5-trisphosphorothioate | very potent inhibitor | Rattus norvegicus | |
L-myo-inositol 1,4,5-trisphosphorothioate | very potent inhibitor | Homo sapiens | |
L-myo-inositol 1,4,5-trisphosphorothioate | very potent inhibitor | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-myo-inositol 1,4,5-trisphosphate + H2O | Homo sapiens | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | Rattus norvegicus | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
SH-SY5Y neuroblastoma cells | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
erythrocyte | ghosts | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Homo sapiens | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Rattus norvegicus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
D-myo-inositol 1,4,5-trisphosphate + H2O | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000023 | - |
L-chiro-Inositol 2,3,5-trisphosphorothioate | - |
Homo sapiens | |
0.0000003 | - |
L-chiro-Inositol 1,4,6-trisphosphorothioate | - |
Homo sapiens | |
0.00000043 | - |
L-myo-inositol 1,4,5-trisphosphorothioate | - |
Homo sapiens | |
0.00000052 | - |
L-myo-inositol 1,3,5-trisphosphorothioate | - |
Homo sapiens |