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Literature summary for 3.1.3.56 extracted from

  • Safrany, S.T.; Mills, S.J.; Liu, C.; Lampe, D.; Noble, N.J.; Nahorski, S.R.; Potter, B.V.L.
    Design of potent and selective inhibitors of myo-inositol 1,4,5-trisphosphate 5-phosphatase (1994), Biochemistry, 33, 10763-10769.
    View publication on PubMed

Application

Application Comment Organism
medicine potential target for drugs Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
L-chiro-Inositol 1,4,6-trisphosphorothioate very potent inhibitor Homo sapiens
L-chiro-Inositol 1,4,6-trisphosphorothioate very potent inhibitor Rattus norvegicus
L-chiro-Inositol 2,3,5-trisphosphorothioate very potent inhibitor Homo sapiens
L-chiro-Inositol 2,3,5-trisphosphorothioate very potent inhibitor Rattus norvegicus
L-myo-inositol 1,3,5-trisphosphorothioate very potent inhibitor Homo sapiens
L-myo-inositol 1,3,5-trisphosphorothioate very potent inhibitor Rattus norvegicus
L-myo-inositol 1,4,5-trisphosphorothioate very potent inhibitor Homo sapiens
L-myo-inositol 1,4,5-trisphosphorothioate very potent inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-myo-inositol 1,4,5-trisphosphate + H2O Homo sapiens regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O Rattus norvegicus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
SH-SY5Y neuroblastoma cells
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
erythrocyte ghosts Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-myo-inositol 1,4,5-trisphosphate + H2O
-
Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O
-
Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
?
D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000023
-
L-chiro-Inositol 2,3,5-trisphosphorothioate
-
Homo sapiens
0.0000003
-
L-chiro-Inositol 1,4,6-trisphosphorothioate
-
Homo sapiens
0.00000043
-
L-myo-inositol 1,4,5-trisphosphorothioate
-
Homo sapiens
0.00000052
-
L-myo-inositol 1,3,5-trisphosphorothioate
-
Homo sapiens