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Literature summary for 3.1.3.56 extracted from
- Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets (1989), J. Biol. Chem., 264, 8873-8877.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Inositol 1,3,4,5-tetrakisphosphate | - |
Homo sapiens |  |
| inositol 1,4-bisphosphate | - |
Homo sapiens | |
| Mg2+ | above 3 mM | Homo sapiens | |
| phosphate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0075 | - |
D-myo-Inositol 1,3,4,5-tetrakisphosphate | - |
Homo sapiens | |
| 0.016 | 0.019 | D-myo-inositol 1,4,5-trisphosphate | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | no effect | Homo sapiens | |
| Mg2+ | required, maximum activity with 1-3 mM, inhibitory above 3 mM | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 75000 | - |
gel filtration, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | Homo sapiens | - |
D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,4,5-trisphosphate + H2O | Homo sapiens | - |
D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | 75000 Da enzyme not phosphorylated | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| platelet | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 25 | - |
purified enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | - |
Homo sapiens | D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | very poor substrate | Homo sapiens | D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Homo sapiens | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| inositol 1,2-cyclic 4,5-trisphosphate + H2O | poor substrate | Homo sapiens | ? | - |
? | |
| additional information | glycerophosphoinositol 4,5-bisphosphate is not hydrolyzed | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 75000, gel filtration, SDS-PAGE | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0006 | - |
Inositol 1,3,4,5-tetrakisphosphate | 45000 Da enzyme | Homo sapiens | |
| 0.015 | - |
Inositol 1,3,4,5-tetrakisphosphate | 75000 Da enzyme | Homo sapiens | |
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