Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.56 extracted from

  • Milani, D.; Volpe, P.; Pozzan, T.
    D-myo-Inositol 1,4,5-trisphosphate phosphatase in skeletal muscle (1988), Biochem. J., 254, 525-529.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.56

Inhibitors

Inhibitors Comment Organism Structure
2,3-bisphosphoglycerate
-
 Frog
2,3-bisphosphoglycerate
-
 Oryctolagus cuniculus
ATP
-
 Frog
ATP
-
 Oryctolagus cuniculus
CdCl2
-
 Oryctolagus cuniculus
D-fructose 1,6-bisphosphate
-
 Oryctolagus cuniculus
D-fructose 2,6-bisphosphate
-
 Oryctolagus cuniculus
D-Glucose 1,6-bisphosphate
-
 Oryctolagus cuniculus
EDTA
-
 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016 0.019 D-myo-inositol 1,4,5-trisphosphate membrane bound enzyme, pH 7.2, 30°C Oryctolagus cuniculus
0.024
-
 D-myo-inositol 1,4,5-trisphosphate soluble enzyme, pH 7.2, 30°C Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane sarcotubular membrane, 60-65% of total activity Oryctolagus cuniculus 16020
-
soluble 35-40% of total activity Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-myo-inositol 1,4,5-trisphosphate + H2O Oryctolagus cuniculus involved in regulation of excitation-contraction coupling in skeletal muscle D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O Oryctolagus cuniculus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O Frog regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Frog
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Oryctolagus cuniculus
-
liver
-
 Oryctolagus cuniculus
-
muscle fast-twitch skeletal muscle Oryctolagus cuniculus
-
muscle fast-twitch skeletal muscle Frog
-
muscle smooth muscle of pulmonary artery Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0006
-
 muscle, pH 7.2, 30°C Frog
0.0014
-
 muscle and liver, pH 7.2, 30°C Oryctolagus cuniculus
0.003
-
 main pulmonary artery, pH 7.2, 30°C Oryctolagus cuniculus
0.0047
-
 brain, pH 7.2, 30°C Oryctolagus cuniculus
0.02
-
 Vmax, membrane fraction, pH 7.2, 30°C Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Oryctolagus cuniculus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Frog D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O involved in regulation of excitation-contraction coupling in skeletal muscle Oryctolagus cuniculus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Oryctolagus cuniculus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Frog D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?