Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.5 extracted from

  • Saeed, A.; Ejaz, S.; Shehzad, M.; Hassan, S.; Al-Rashida, M.; Lecka, J.; Sevigny, J.; Iqbal, J.
    3-(5-(Benzylideneamino)thiazol-3-yl)-2H-chromen-2-ones A new class of alkaline phosphatase and ecto-5'-nucleotidase inhibitors (2016), RSC Adv., 6, 21026-21036 .
No PubMed abstract available
Search for more literature for 3.1.3.5

Inhibitors

Inhibitors Comment Organism Structure
3-(2-(3,4,5-trimethoxybenzylideneamino)thiazol-4-yl)-2Hchromen-2-one
-
 Homo sapiens
3-(2-(3,4,5-trimethoxybenzylideneamino)thiazol-4-yl)-2Hchromen-2-one
-
 Rattus norvegicus
3-(2-(3-chlorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Homo sapiens
3-(2-(3-chlorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Rattus norvegicus
3-(2-(3-methoxy-4-phenoxybenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Homo sapiens
3-(2-(3-methoxy-4-phenoxybenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Rattus norvegicus
3-(2-(3-nitrobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Homo sapiens
3-(2-(3-nitrobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Rattus norvegicus
3-(2-(4-bromobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Homo sapiens
3-(2-(4-bromobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Rattus norvegicus
3-(2-(4-chlorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Homo sapiens
3-(2-(4-chlorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Rattus norvegicus
3-(2-(4-fluorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Homo sapiens
3-(2-(4-fluorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Rattus norvegicus
3-(2-(furan-2-ylmethyleneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Homo sapiens
3-(2-(furan-2-ylmethyleneamino)thiazol-4-yl)-2H-chromen-2-one
-
 Rattus norvegicus
sulfamic acid
-
 Homo sapiens
sulfamic acid
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 1 mM used in assay conditions Homo sapiens
Ca2+ 1 mM used in assay conditions Rattus norvegicus
Mg2+ 2 mM used in assay conditions Homo sapiens
Mg2+ 2 mM used in assay conditions Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Homo sapiens adenosine + phosphate
-
 ?
5'-AMP + H2O
-
 Rattus norvegicus adenosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
e5'NT
-
 Homo sapiens
e5'NT
-
 Rattus norvegicus
ecto-5'-nucleotidase
-
 Homo sapiens
ecto-5'-nucleotidase
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00025
-
 at pH 7.4 and 37°C Homo sapiens 3-(2-(3-nitrobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
0.00028
-
 at pH 7.4 and 37°C Homo sapiens 3-(2-(4-chlorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
0.00041
-
 at pH 7.4 and 37°C Homo sapiens 3-(2-(3-methoxy-4-phenoxybenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
0.000438
-
 at pH 7.4 and 37°C Homo sapiens 3-(2-(4-bromobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
0.00092
-
 at pH 7.4 and 37°C Homo sapiens 3-(2-(furan-2-ylmethyleneamino)thiazol-4-yl)-2H-chromen-2-one
0.00223
-
 at pH 7.4 and 37°C Homo sapiens 3-(2-(3-chlorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
0.00515
-
 at pH 7.4 and 37°C Homo sapiens 3-(2-(4-fluorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
0.0102
-
 at pH 7.4 and 37°C Homo sapiens 3-(2-(3,4,5-trimethoxybenzylideneamino)thiazol-4-yl)-2Hchromen-2-one
0.0421
-
 at pH 7.4 and 37°C Homo sapiens sulfamic acid
0.0773
-
 at pH 7.4 and 37°C Rattus norvegicus sulfamic acid