Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.5 extracted from

  • Bertoni, A.P.S.; Bracco, P.A.; de Campos, R.P.; Lutz, B.S.; Assis-Brasil, B.M.; Meyer, E.L.S.; Saffi, J.; Braganhol, E.; Furlanetto, T.W.; Wink, M.R.
    Activity of ecto-5'-nucleotidase (NT5E/CD73) is increased in papillary thyroid carcinoma and its expression is associated with metastatic lymph nodes (2019), Mol. Cell. Endocrinol., 479, 54-60 .
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is a target for papillary thyroid carcinoma therapy Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 2 mM used in assay conditions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P21589
-
-

Source Tissue

Source Tissue Comment Organism Textmining
papillary thyroid cancer cell
-
Homo sapiens
-
thyroid cell line
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
Homo sapiens adenosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
CD73
-
Homo sapiens
ecto-5'-nucleotidase
-
Homo sapiens
NT5E
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is higher in papillary thyroid carcinoma cells than in the adjacent non-malignant thyroid tissue up