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Literature summary for 3.1.3.5 extracted from

  • Kao, D.J.; Saeedi, B.J.; Kitzenberg, D.; Burney, K.M.; Dobrinskikh, E.; Battista, K.D.; Vazquez-Torres, A.; Colgan, S.P.; Kominsky, D.J.
    Intestinal epithelial ecto-5'-nucleotidase (CD73) regulates intestinal colonization and infection by nontyphoidal Salmonella (2017), Infect. Immun., 85, e01022-16 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-AMP + H2O Mus musculus
-
 adenosine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q61503
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestinal epithelial cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Mus musculus adenosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CD73
-
 Mus musculus
ecto-5'-nucleotidase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the knockdown of enzyme expression in cultured intestinal epithelial cells results in dramatic defects in intraepithelial localization and replication as well as defective transepithelial translocation by Salmonella spp. Mus musculus
physiological function the enzyme is essential for the production of luminal adenosine in the gut in vivo Mus musculus