Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2,3-bisphosphoglycerate | - |
Homo sapiens | |
ATP | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Km-value for viramidine is above 0.5 mM | Homo sapiens | |
0.024 | - |
ribavirin | presence of 2 mM ATP, phosphate-buffered saline, pH 7.4 | Homo sapiens | |
0.047 | - |
ribavirin | presence of 0.4 mM 2,3-bisphosphoglycerate, Tris-buffer, pH 7.4 | Homo sapiens | |
0.088 | - |
ribavirin | presence of 0.4 mM 2,3-bisphosphoglycerate, phosphate-buffered saline, pH 7.4 | Homo sapiens | |
0.095 | - |
ribavirin | presence of 2 mM ATP, Tris-buffer, pH 7.4 | Homo sapiens | |
1.8 | - |
Inosine | presence of 0.4 mM 2,3-bisphosphoglycerate, Tris-buffer, pH 7.4 | Homo sapiens | |
2.17 | - |
Inosine | presence of 2 mM ATP, Tris-buffer, pH 7.4 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P49902 | isoform cytosolic 5'-nucleotidase II, expression in Escherichia coli | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine + 5'-IMP | - |
Homo sapiens | 5'-IMP + inosine | - |
? | |
ribavirin + 5'-IMP | better substrate than viramidine | Homo sapiens | ? | - |
? | |
viramidine + 5'-IMP | worse substrate than ribavirin | Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.023 | - |
ribavirin | presence of 2 mM ATP, phosphate-buffered saline, pH 7.4 | Homo sapiens | |
0.027 | - |
ribavirin | presence of 0.4 mM 2,3-bisphosphoglycerate, Tris-buffer, pH 7.4 | Homo sapiens | |
0.067 | - |
ribavirin | presence of 0.4 mM 2,3-bisphosphoglycerate, PBS-buffer, pH 7.4 | Homo sapiens | |
0.15 | - |
ribavirin | presence of 2 mM ATP, Tris-buffer, pH 7.4 | Homo sapiens | |
19 | - |
Inosine | presence of 0.4 mM 2,3-bisphosphoglycerate, Tris-buffer, pH 7.4 | Homo sapiens | |
22 | - |
Inosine | presence of 2 mM ATP, Tris-buffer, pH 7.4 | Homo sapiens |