Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.892 | - |
4-nitrophenyl phosphate | pH 5.5 | Rattus norvegicus | |
0.953 | - |
4-methylumbelliferyl phosphate | pH 5.5 | Rattus norvegicus | |
1.19 | - |
1-naphthyl phosphate | pH 7.5 | Rattus norvegicus | |
1.88 | - |
1-naphthyl phosphate | pH 5.5 | Rattus norvegicus | |
2.01 | - |
phosphotyrosine | pH 5.5 | Rattus norvegicus | |
2.04 | - |
Phenyl phosphate | pH 5.5 | Rattus norvegicus | |
2.41 | - |
4-methylumbelliferyl phosphate | pH 7.5 | Rattus norvegicus | |
5.05 | - |
4-nitrophenyl phosphate | pH 7.5 | Rattus norvegicus | |
18.3 | - |
Phenyl phosphate | pH 7.5 | Rattus norvegicus | |
21.7 | - |
phosphotyrosine | pH 7.5 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | the PTPase family contains both cell surface transmembrane receptor forms and cytolasmic nonreceptor forms. The receptor forms generally have an extracellular domain, a single transmembrane region, and one or two cytoplasmic PTPase domains. The intracellular PTPases contain a single catalytic domain and various amino- or carboxy-terminal extensions including SH2-domains that may have targeting or regulatory functions. The catalytic domain is the only structural element with an amino acid sequence identical among all PTPases from bacteria to mammals | Rattus norvegicus | 5829 | - |
plasma membrane | the PTPase family contains both cell surface transmembrane receptor forms and cytoplasmic nonreceptor forms. The receptor forms generally have an extracellular domain, a single transmembrane region, and one or two cytoplasmic PTPase domains. The intracellular PTPases contain a single catalytic domain and various amino- or carboxy-terminal extensions including SH2-domains that may have targeting or regulatory functions. The catalytic domain is the only structural element with an amino acid sequence identical among all PTPases from bacteria to mammals | Rattus norvegicus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | protein-tyrosine phosphatases are signaling molecules that are involved in numerous cellular mechanisms such as cell growth and proliferation, cell cycle regulation, and cytoskeletal integrity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-naphthyl phosphate + H2O | - |
Rattus norvegicus | 1-naphthol + phosphate | - |
? | |
4-methylumbelliferyl phosphate + H2O | - |
Rattus norvegicus | 4-methylumbelliferone + phosphate | - |
? | |
4-nitrophenyl phosphate + H2O | - |
Rattus norvegicus | 4-nitrophenol + phosphate | - |
? | |
additional information | protein-tyrosine phosphatases are signaling molecules that are involved in numerous cellular mechanisms such as cell growth and proliferation, cell cycle regulation, and cytoskeletal integrity | Rattus norvegicus | ? | - |
? | |
phenyl phosphate + H2O | - |
Rattus norvegicus | phenol + phosphate | - |
? | |
phosphotyrosine + H2O | - |
Rattus norvegicus | tyrosine + phosphate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.34 | - |
1-naphthyl phosphate | pH 7.5 | Rattus norvegicus | |
5.32 | - |
1-naphthyl phosphate | pH 5.5 | Rattus norvegicus | |
10.1 | - |
4-methylumbelliferyl phosphate | pH 7.5 | Rattus norvegicus | |
11.6 | - |
4-nitrophenyl phosphate | pH 7.5 | Rattus norvegicus | |
11.8 | - |
Phenyl phosphate | pH 7.5 | Rattus norvegicus | |
13.1 | - |
phosphotyrosine | pH 7.5 | Rattus norvegicus | |
64.9 | - |
Phenyl phosphate | pH 5.5 | Rattus norvegicus | |
72.9 | - |
phosphotyrosine | pH 5.5 | Rattus norvegicus | |
75.3 | - |
4-nitrophenyl phosphate | pH 5.5 | Rattus norvegicus | |
79.9 | - |
4-methylumbelliferyl phosphate | pH 5.5 | Rattus norvegicus |