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Literature summary for 3.1.3.48 extracted from

  • Parker, E.J.
    The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3 (2015), Structure, 23, 608-609 .
    View publication on PubMed
Search for more literature for 3.1.3.48

Protein Variants

Protein Variants Comment Organism
D811E site-directed mutagenesis, ectopic expression of the D811E mutant form of PTPN3 does not reduce phosphorylation of substrate peptide Eps15 Homo sapiens
H812F site-directed mutagenesis, ectopic expression of the H812F mutant form of PTPN3 does not reduce phosphorylation of substrate peptide Eps15 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[a protein]-tyrosine phosphate + H2O Homo sapiens
-
 [a protein]-tyrosine + phosphate
-
 ?
[Eps15 peptide]-tyrosine phosphate + H2O Homo sapiens substrate is a phosphopeptide fragment of substrate epidermal growth factor receptor. Eps15 is a scaffolding adaptor that regulates endocytosis and trafficking of the EGFR and is a substrate for enzyme PTPN3 [Eps15 peptide]-tyrosine + phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P26045
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[a protein]-tyrosine phosphate + H2O
-
 Homo sapiens [a protein]-tyrosine + phosphate
-
 ?
[Eps15 peptide]-tyrosine phosphate + H2O substrate is a phosphopeptide fragment of substrate epidermal growth factor receptor. Eps15 is a scaffolding adaptor that regulates endocytosis and trafficking of the EGFR and is a substrate for enzyme PTPN3 Homo sapiens [Eps15 peptide]-tyrosine + phosphate
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 ?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase
-
 Homo sapiens
PTP
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 Homo sapiens
PTPN3
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 Homo sapiens

General Information

General Information Comment Organism
evolution analysis of molecular basis of substrate specificity in the FERM-containing subfamily of nonreceptor PTPs, overview. These enzymes are characterized by the presence of an N-terminal FERM plasma-membrane-localization domain and a C-terminal catalytic domain Homo sapiens
additional information determination of key interactions that likely determine both substrate recognition and the catalytic activity of the complex. e.g. an important interaction between H812 of the enzyme and a proline residue adjacent to the phosphotyrosine of the peptide substrate, which results in an atypical conformation of the C-terminal part of the peptide substrate. If the proline is replaced by valine, the atypical conformation is lost. Residues H812 and D811 of PTPN3 are not required to regulate Eps15-dependent EGFR signaling in cultured cells Homo sapiens
physiological function protein tyrosine phosphatases (PTPs) play critical roles in cell signaling pathways. Together with the protein kinases, they control the balance of phosphorylated species, enabling specific and varied signaling responses Homo sapiens