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Literature summary for 3.1.3.48 extracted from
- A phosphoglycolate phosphatase/AUM-dependent link between triacylglycerol turnover and epidermal growth factor signaling (2018), Biochim. Biophys. Acta, 1863, 584-594 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q8CHP8 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| GC-1 spg cell | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pgp | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | PGP depletion facilitates fatty acid flux through the intracellular triacylglycerol/fatty acid cycle, and phosphatidylinositol-4,5-bisphosphate is critical for the impact of PGP activity on EGF-induced signaling. Loss of endogenous PGP expression amplifies both EGF-induced EGF receptor autophosphorylation and Src-dependent tyrosine phosphorylation of phospholipase C-gamma1. EGF enhances the formation of circular dorsal ruffles in PGP-depleted cells via Src/PLCgamma1/protein kinase C (PKC)-dependent signaling to the cytoskeleton | Mus musculus |
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Release 2023.1 (January 2023)
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