Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calopocarpin | - |
Homo sapiens | |
erybraedin A | - |
Homo sapiens | |
erylysins A | i.e. 3''-hydroxy-2',2'-dimethylpyrano[6',5':3,4]-2'',2''-dimethyldihydropyrano[6'',5'':9,10]pterocarpan, a pterocarpan isolated from stem bark of Erythrina lysistemon, inhibits PTPB1 | Homo sapiens | |
erylysins B | i.e. furano[5',4':3,4]-9-hydroxy-10-prenylpterocarpan, a pterocarpan isolated from stem bark of Erythrina lysistemon, inhibits PTPB1 | Homo sapiens | |
erysubin D | - |
Homo sapiens | |
eryvarin D | - |
Homo sapiens | |
isoneorautenol | - |
Homo sapiens | |
additional information | the substitution of prenyl groups on pterocarpans might be important for in vitro PTP1B inhibitory activity, and hydroxyl group attached to C-6a or an aldehyde group attached to C-8 may decrease this activity. No inhibition by erylysins C, i.e. 8-formyl-3,9-dihydroxy-4,10-diprenylpterocarpan, by cristacarpin, and by erystagallin C | Homo sapiens | |
orientanol C | - |
Homo sapiens | |
phaseollin | - |
Homo sapiens | |
ursolic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant enzyme | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase 1B | - |
Homo sapiens |
PTPB1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
assay at | Homo sapiens |