Application | Comment | Organism |
---|---|---|
drug development | MptpB is a promising target for anti-tuberculosis drug development | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
F1S-6C-W11 | - |
Mycobacterium tuberculosis | |
H1-5C-W11 | - |
Mycobacterium tuberculosis | |
additional information | PTP bidentate inhibitor library synthesis and screening, overview. The bidentate inhibitors have three components: 1. the warheads, alkyne-containing N-phenyloxamic acids that are cell-permeable, potent bioisosteric phosphotyrosine mimics, 2. a variety of different types of building blocks that act as the secondary-site binders, and 3. azide-containing linkers of different lengths joining the warhead and the building blocks, overview | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme is a member of the PTP family | Mycobacterium tuberculosis |
MPtpB | - |
Mycobacterium tuberculosis |
protein tyrosine phosphatase B | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00015 | - |
F1S-6C-W11 | - |
Mycobacterium tuberculosis | |
0.00017 | - |
H1-5C-W11 | - |
Mycobacterium tuberculosis |