Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(Z)-2-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-3-(2-(2-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid | - |
Homo sapiens | |
(Z)-3-(2-(2-nitrophenyl)hydrazono)-2-oxoindoline-5-sulfonic acid | NSC-117199 | Homo sapiens | |
(Z)-3-(2-(3-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid | - |
Homo sapiens | |
(Z)-3-(2-(5-(4-chlorobenzylcarbamoyl)-2-oxoindolin-3-ylidene)-hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-3-(2-(5-(N-(2,4-dichlorophenethyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-3-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-3-(2-(5-(N-(3-chloro-4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-3-(2-(5-(N-(3-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-3-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-3-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-3-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-3-(2-(5-(N-(4-methylbenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-4-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-4-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-4-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-4-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | - |
Homo sapiens | |
(Z)-4-(2-(5-(N-benzylsulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl) benzoic acid | - |
Homo sapiens | |
3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide | - |
Homo sapiens | |
3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 4-chlorobenzylamide | - |
Homo sapiens | |
3-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid | - |
Homo sapiens | |
4-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid | - |
Homo sapiens | |
N,N'-[benzene-1,4-diylbis(propane-2,2-diylbenzene-4,1-diyl)]bis(1,1,1-trifluoromethanesulfonamide) | - |
Homo sapiens | |
N-([4-[difluoro(phosphono)methyl]phenyl]acetyl)-a-aspartyl-4-[difluoro(phosphono)methyl]phenylalaninamide | - |
Homo sapiens | |
NAT6-297775 | - |
Homo sapiens | |
NSC-87877 | potent Shp2 and Shp1 inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6,8-difluoro-4-methylumbelliferyl phosphate + H2O | - |
Homo sapiens | 6,8-difluoro-4-methylumbelliferol + phosphate | - |
? | |
phosphorylated c-MET + H2O | - |
Homo sapiens | c-MET + phosphate | - |
? | |
phosphorylated ErbB1 + H2O | - |
Homo sapiens | ErbB1 + phosphate | - |
? | |
phosphorylated ErbB2 + H2O | - |
Homo sapiens | ErbB2 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Homo sapiens |
protein tyrosine phosphatase 1B | - |
Homo sapiens |
PTP | - |
Homo sapiens |
PTP1B | - |
Homo sapiens |
SHP1 | - |
Homo sapiens |
SHP2 | Shp2 is a nonreceptor PTP that plays a positive role in cell signaling by growth factors and cytokines and is involved in regulation of cell proliferation, differentiation, and migration | Homo sapiens |
Src homology-2 domain containing protein tyrosine phosphatase-1 | - |
Homo sapiens |
Src homology-2 domain containing protein tyrosine phosphatase-2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0003 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | NSC-87877 | |
0.0008 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(2-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid | |
0.001 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0013 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-benzylsulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl) benzoic acid | |
0.0014 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0015 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(2-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid | |
0.0018 | - |
- |
Homo sapiens | N,N'-[benzene-1,4-diylbis(propane-2,2-diylbenzene-4,1-diyl)]bis(1,1,1-trifluoromethanesulfonamide) | |
0.0025 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-benzylsulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl) benzoic acid | |
0.0025 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | NAT6-297775 | |
0.0038 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(3-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0044 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 4-chlorobenzylamide | |
0.0045 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 3-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid | |
0.0045 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 4-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid | |
0.0048 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(3-chloro-4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.005 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-methylbenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0052 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(2,4-dichlorophenethyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0055 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0059 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0063 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0071 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-benzylsulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl) benzoic acid | |
0.0074 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0075 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0083 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0093 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 4-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid | |
0.0098 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 4-chlorobenzylamide | |
0.01 | - |
- |
Homo sapiens | N-([4-[difluoro(phosphono)methyl]phenyl]acetyl)-a-aspartyl-4-[difluoro(phosphono)methyl]phenylalaninamide | |
0.0106 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0108 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0113 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-methylbenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0114 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0117 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0119 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide | |
0.0145 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0154 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(3-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0154 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(2-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid | |
0.0157 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 3-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid | |
0.0158 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(3-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid | |
0.0159 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.018 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0181 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0183 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0188 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0193 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(2,4-dichlorophenethyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0194 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0194 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(4-chlorobenzylcarbamoyl)-2-oxoindolin-3-ylidene)-hydrazinyl)benzoic acid | |
0.0223 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(4-chlorobenzylcarbamoyl)-2-oxoindolin-3-ylidene)-hydrazinyl)benzoic acid | |
0.0229 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-2-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0257 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-2-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0277 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 4-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid | |
0.0324 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-2-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0326 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-methylbenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0328 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0371 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 3-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid | |
0.0382 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(3-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid | |
0.0409 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 4-chlorobenzylamide | |
0.0425 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(3-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0431 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0468 | - |
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(2-nitrophenyl)hydrazono)-2-oxoindoline-5-sulfonic acid | |
0.0549 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(3-chloro-4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0608 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-4-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0631 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.068 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(2-nitrophenyl)hydrazono)-2-oxoindoline-5-sulfonic acid | |
0.0724 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(3-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid | |
0.0734 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(2,4-dichlorophenethyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0742 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.0967 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(2-nitrophenyl)hydrazono)-2-oxoindoline-5-sulfonic acid | |
0.1037 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide | |
0.1228 | - |
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(N-(3-chloro-4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid | |
0.1566 | - |
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide | |
0.3 | - |
IC50 above 0.3 mM, PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C | Homo sapiens | (Z)-3-(2-(5-(4-chlorobenzylcarbamoyl)-2-oxoindolin-3-ylidene)-hydrazinyl)benzoic acid |