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Literature summary for 3.1.3.48 extracted from

  • Yu, X.; Sun, J.P.; He, Y.; Guo, X.; Liu, S.; Zhou, B.; Hudmon, A.; Zhang, Z.Y.
    Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases (2007), Proc. Natl. Acad. Sci. USA, 104, 19767-19772.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C129S decreased activity Homo sapiens
F28A decreased activity Homo sapiens
K138A increased activity Homo sapiens
L29A decreased activity Homo sapiens
R33A decreased activity Homo sapiens
S35E decreased activity Homo sapiens
S35E/T36E increased activity Homo sapiens
T36E decreased activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6-hydroxy-3-[1-[4-(naphthalen-1-ylamino)-4-oxobutyl]-1H-1,2,3-triazol-4-yl]-2-phenyl-1-benzofuran-5-carboxylic acid
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4
-
p-nitrophenyl phosphate mutant enzyme C129S, at pH 7.0 and 25°C Homo sapiens
2.4
-
p-nitrophenyl phosphate mutant enzyme T36E, at pH 7.0 and 25°C Homo sapiens
2.8
-
p-nitrophenyl phosphate mutant enzyme K138A, at pH 7.0 and 25°C Homo sapiens
3.8
-
p-nitrophenyl phosphate mutant enzyme R33A, at pH 7.0 and 25°C Homo sapiens
3.9
-
p-nitrophenyl phosphate mutant enzyme L29A, at pH 7.0 and 25°C Homo sapiens
4
-
p-nitrophenyl phosphate mutant enzyme F28A, at pH 7.0 and 25°C Homo sapiens
4.2
-
p-nitrophenyl phosphate wild type enzyme, at pH 7.0 and 25°C Homo sapiens
4.5
-
p-nitrophenyl phosphate mutant enzyme S35E, at pH 7.0 and 25°C Homo sapiens
6.9
-
p-nitrophenyl phosphate mutant enzyme S35E/T36E, at pH 7.0 and 25°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-nitrophenyl phosphate + H2O
-
Homo sapiens p-nitrophenol + phosphate
-
?
phosphorylated Src protein + H2O
-
Homo sapiens Src protein + phosphate
-
?

Synonyms

Synonyms Comment Organism
lymphoid-specific tyrosine phosphatase
-
Homo sapiens
LyP
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.37
-
p-nitrophenyl phosphate mutant enzyme T36E, at pH 7.0 and 25°C Homo sapiens
0.56
-
p-nitrophenyl phosphate mutant enzyme L29A, at pH 7.0 and 25°C Homo sapiens
0.59
-
p-nitrophenyl phosphate mutant enzyme S35E, at pH 7.0 and 25°C Homo sapiens
0.61
-
p-nitrophenyl phosphate mutant enzyme R33A, at pH 7.0 and 25°C Homo sapiens
0.67
-
p-nitrophenyl phosphate mutant enzyme F28A, at pH 7.0 and 25°C Homo sapiens
0.7
-
p-nitrophenyl phosphate wild type enzyme, at pH 7.0 and 25°C Homo sapiens
0.73
-
p-nitrophenyl phosphate mutant enzyme C129S, at pH 7.0 and 25°C Homo sapiens
0.81
-
p-nitrophenyl phosphate mutant enzyme K138A, at pH 7.0 and 25°C Homo sapiens
0.89
-
p-nitrophenyl phosphate mutant enzyme S35E/T36E, at pH 7.0 and 25°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0046
-
-
Homo sapiens 6-hydroxy-3-[1-[4-(naphthalen-1-ylamino)-4-oxobutyl]-1H-1,2,3-triazol-4-yl]-2-phenyl-1-benzofuran-5-carboxylic acid