Cloned (Comment) | Organism |
---|---|
expressed in insect cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapour diffusion method with 0.2 M MgCl2, 4.5% PEG 10000 (w/v) and 0.1 M HEPES (pH 7.5) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
small t antigen | small t antigen of DNA tumor virus SV40 inhibits the phosphatase activity of the PP2A core enzyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0024 | - |
p-nitrophenyl phosphate | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
glutathione affinity column chromatography, Source 15Q column chromatography, and Superdex 200 gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
p-nitrophenyl phosphate + H2O | - |
Homo sapiens | p-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PP2A | - |
Homo sapiens |
protein phosphatase 2A | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | - |
using p-nitrophenyl phosphate as a substrate | Homo sapiens | small t antigen |