Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.48 extracted from

  • Seiner, D.R.; LaButti, J.N.; Gates, K.S.
    Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein (2007), Chem. Res. Toxicol., 20, 1315-1320.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.48

Inhibitors

Inhibitors Comment Organism Structure
3-methyl-2-butenal 95% remaining activity at 0.5 mM Homo sapiens
acetaldehyde more than 95% remaining activity at 0.5 mM Homo sapiens
acrolein 4% remaining activity at 0.5 mM, potent irreversible time-dependent inhibitor, addition of 1 mM vanadate slows inactivation of PTP1B by 0.5 mM acrolein Homo sapiens
crotonaldehyde 85% remaining activity at 0.5 mM Homo sapiens
Glyoxal 93% remaining activity at 0.5 mM Homo sapiens
additional information the presence of the superoxide- and hydrogen peroxide-destroying enzymes superoxide dismutase and catalase has no effect on the rate of the inactivation reaction Homo sapiens
propanal 93% remaining activity at 0.5 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-nitrophenyl phosphate + H2O
-
 Homo sapiens p-nitrophenol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
 Homo sapiens
PTP1B
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00023
-
 acrolein in sodium acetate (100 mM), bis-Tris (50 mM), Tris (50 mM), diethylenetriaminepentaacetic acid (5 mM), and 2,5-dimethylfuran (5% v/v), at pH 7 and 25°C Homo sapiens