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Literature summary for 3.1.3.48 extracted from

  • Fukaya, Y.; Yamaguchi, M.
    Characterization of protein tyrosine phosphatase activity in rat liver microsomes: suppressive effect of endogenous regucalcin in transgenic rats (2004), Int. J. Mol. Med., 14, 427-432.
    View publication on PubMed
Search for more literature for 3.1.3.48

Activating Compound

Activating Compound Comment Organism Structure
CaCl2 0.01 mM, significant enhancement of activity Rattus norvegicus
Calmodulin 0.0025 to 0.005 mM, significant enhancement of activity Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information enzyme activity is significantly suppressed in the liver microsomes of regucalcin transgenic rats Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information in absence of externally added Ca2+, no effect of ethylene glycol bis(2-amino-ethylether) N,N,NĀ’,NĀ’-tetracetic acid or trifluoperazine. Not inhibitory: okadaic acid Rattus norvegicus
regucalcin regulatory protein in intracellular signaling Rattus norvegicus
vanadate
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoserine + H2O
-
 Rattus norvegicus serine + phosphate
-
 ?
phosphothreonine + H2O
-
 Rattus norvegicus threonine + phosphate
-
 ?
phosphotyrosine + H2O best substrate Rattus norvegicus tyrosine + phosphate
-
 ?