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Literature summary for 3.1.3.47 extracted from

  • Feingold K.R.; Wiley M.H.; Moser A.H.; Lear S.R.; Siperstein M.D.
    Inhibition of HMG-CoA reductase by its substrates (1982), Biochem. Biophys. Res. Commun., 107, 1376-1383.
    View publication on PubMed
Search for more literature for 3.1.3.47

Inhibitors

Inhibitors Comment Organism Structure
hydroxymethylglutaryl-CoA does not inhibit the reductase phosphatase itself but interacts with the reductase and prevents its activation Rattus norvegicus
NADPH does not inhibit the reductase phosphatase itself but interacts with the reductase and prevents its activation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O
-
 Rattus norvegicus [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate
-
 ?
[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O
-
 Rattus norvegicus ?
-
 ?