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Literature summary for 3.1.3.47 extracted from
- Purification and properties of two native, high-molecular-weight hydroxymethylglutaryl-CoA reductase phosphatases (1983), Biochim. Biophys. Acta, 751, 218-229.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diphosphate | - |
Rattus norvegicus |  |
| fluoride | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 120000 | - |
cytosolic isoenzyme II, gel chromatography | Rattus norvegicus |
| 190000 | - |
cytosolic isoenzyme I, gel chromatography | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | Rattus norvegicus | - |
? | - |
? | |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| Acetone | after treatment with acetone a catalytic subunit of ~35000 Da is obtained, activity increased | Rattus norvegicus |
| Ethanol | after treatment with this solvent a catalytic subunit of 32000-35000 Da is obtained, activity increased | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| liver | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| HMG-CoA reductase kinase phosphate + H2O | - |
Rattus norvegicus | HMG-CoA reductase kinase + phosphate | - |
? | |
| phosphorylase a phosphate + H2O | - |
Rattus norvegicus | phosphorylase a + phosphate | - |
? | |
| [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | - |
Rattus norvegicus | [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate | - |
? | |
| [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | - |
Rattus norvegicus | ? | - |
? | |
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